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Literature summary for 1.1.1.153 extracted from

  • Yoon, K.H.; Cha, K.W.; Park, S.I.; Yim, J.J.
    Isolation and characterization of sepiapterin reductase from Drosophila melanogaster (1993), Pteridines, 4, 43-50.
No PubMed abstract available

Inhibitors

Inhibitors Comment Organism Structure
acetic acid buffers that contain acetate inhibit activity Drosophila melanogaster
Cd2+ 1 mM inhibits entirely Drosophila melanogaster
Fe3+ 1 mM inhibits entirely Drosophila melanogaster
additional information Li+, Na+, Co2+, Mn2+, Ni2+ show slight inhibition at 1 mM Drosophila melanogaster
NADPH more than 0.05 mM causes substrate inhibition Drosophila melanogaster
Sn2+ 1 mM inhibits entirely Drosophila melanogaster

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0014
-
NADPH
-
Drosophila melanogaster
0.075
-
sepiapterin
-
Drosophila melanogaster

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
38400
-
1 * 38400, SDS-PAGE Drosophila melanogaster
39000
-
gel filtration, nondissociating PAGE Drosophila melanogaster

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6-(S)-lactoyl-7,8-dihydropterin + NADPH Drosophila melanogaster
-
6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
?
6-(S)-lactoyl-7,8-dihydropterin + NADPH Drosophila melanogaster Oregon R
-
6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
?

Organism

Organism UniProt Comment Textmining
Drosophila melanogaster
-
-
-
Drosophila melanogaster Oregon R
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Drosophila melanogaster

Reaction

Reaction Comment Organism Reaction ID
L-erythro-7,8-dihydrobiopterin + NADP+ = sepiapterin + NADPH + H+ enzyme also reduces carbonyl compounds of non-pteridine derivatives Drosophila melanogaster

Storage Stability

Storage Stability Organism
-40°C, in 50 mM potassium phosphate buffer, pH 6.9, at least stable for two months Drosophila melanogaster

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1,2-cyclohexadione + NADPH
-
Drosophila melanogaster ?
-
?
6-(S)-lactoyl-7,8-dihydropterin + NADPH
-
Drosophila melanogaster 6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
?
6-(S)-lactoyl-7,8-dihydropterin + NADPH
-
Drosophila melanogaster Oregon R 6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
?
diacetyl + NADPH
-
Drosophila melanogaster ?
-
?
diacetyl + NADPH
-
Drosophila melanogaster Oregon R ?
-
?
menadione + NADPH
-
Drosophila melanogaster ?
-
?
menadione + NADPH
-
Drosophila melanogaster Oregon R ?
-
?
methylglyoxal + NADPH
-
Drosophila melanogaster ?
-
?
methylglyoxal + NADPH
-
Drosophila melanogaster Oregon R ?
-
?
p-nitrobenzaldehyde + NADPH
-
Drosophila melanogaster p-nitrobenzyl alcohol + NADP+
-
?
phenylglyoxal + NADPH
-
Drosophila melanogaster ?
-
?
phenylglyoxal + NADPH
-
Drosophila melanogaster Oregon R ?
-
?

Subunits

Subunits Comment Organism
monomer 1 * 38400, SDS-PAGE Drosophila melanogaster

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
-
Drosophila melanogaster

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
48
-
half of activity remains within 30 min Drosophila melanogaster

pH Range

pH Minimum pH Maximum Comment Organism
5.7 6.7 optimium for activity, highest activity in phosphate buffer Drosophila melanogaster