Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.1.1.153 extracted from

  • Smith, G.K.
    On the role of sepiapterin reductase in the biosynthesis of tetrahydrobiopterin (1987), Arch. Biochem. Biophys., 255, 254-266.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
additional information inhibition by specific antibody from rabbits Rattus norvegicus
N-acetylserotonin
-
Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information kinetics Rattus norvegicus
0.002
-
pyruvoyltetrahydropterin pH 7.4, 37°C Rattus norvegicus
0.007
-
1'-hydroxy-2'-oxopropyltetrahydropterin pH 7.4, 37°C Rattus norvegicus
0.008
-
lactoyltetrahydropterin pH 7.4, 37°C Rattus norvegicus
0.009
-
sepiapterin pH 7.4, 37°C Rattus norvegicus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
27500
-
2 * 27500, SDS-PAGE Rattus norvegicus
56000
-
second band in SDS-PAGE Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6-(S)-lactoyl-7,8-dihydropterin + NADPH Rattus norvegicus terminal step in the biosynthetic pathway for tetrahydrobiopterin 6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
?
6-(S)-lactoyl-7,8-dihydropterin + NADPH Rattus norvegicus catalyzes the complete reduction of pyrovoyltetrahydropterin to tetrahydrobiopterin 6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-
Rattus norvegicus
-
male sprague-dawley rats
-

Purification (Commentary)

Purification (Comment) Organism
-
Rattus norvegicus
native enzyme from erythrocytes by hydroxylapatite and NADP+-affinity chromatography, to homogeneity Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
adrenal gland
-
Rattus norvegicus
-
blood
-
Rattus norvegicus
-
brain
-
Rattus norvegicus
-
erythrocyte
-
Rattus norvegicus
-
heart
-
Rattus norvegicus
-
kidney
-
Rattus norvegicus
-
liver
-
Rattus norvegicus
-
lung
-
Rattus norvegicus
-
spleen
-
Rattus norvegicus
-
testis
-
Rattus norvegicus
-
thymus
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1'-hydroxy-2'-oxopropyltetrahydropterin + NADP+
-
Rattus norvegicus L-erythro-tetrahydrobiopterin + NADPH
-
?
1'-hydroxy-2'-oxopropyltetrahydropterin + NADPH
-
Rattus norvegicus L-erythrotetrahydrobiopterin + NADP+
-
?
6-(S)-lactoyl-7,8-dihydropterin + NADPH
-
Rattus norvegicus 6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
?
6-(S)-lactoyl-7,8-dihydropterin + NADPH terminal step in the biosynthetic pathway for tetrahydrobiopterin Rattus norvegicus 6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
?
6-(S)-lactoyl-7,8-dihydropterin + NADPH catalyzes the complete reduction of pyrovoyltetrahydropterin to tetrahydrobiopterin Rattus norvegicus 6-(L-erythro-1',2'-dihydroxypropyl)-7,8-dihydropterin + NADP+
-
?
6-pyruvoyltetrahydropterin + 2 NADPH + 2 H+
-
Rattus norvegicus L-erythro-tetrahydrobiopterin + 2 NADP+
-
?
lactoyltetrahydropterin + NADPH
-
Rattus norvegicus L-erythrotetrahydrobiopterin + NADP+
-
?
lactoyltetrahydropterin + NADPH + H+
-
Rattus norvegicus L-erythro-tetrahydrobiopterin + NADP+
-
?
additional information descending substrate preference: sepiapterin, lactoyltetrahydropterin, pyruvoyltetrahydropterin, 1'-hydroxy-2'-oxopropyltetrahydropterin Rattus norvegicus ?
-
?
pyruvoyltetrahydropterin + NADPH
-
Rattus norvegicus L-erythrotetrahydrobiopterin + NADP+
-
?
sepiapterin + NADPH + H+ best substrate Rattus norvegicus dihydrobiopterin + NADP+
-
?

Subunits

Subunits Comment Organism
? x * 56000, SDS-PAGE Rattus norvegicus
homodimer 2 * 27500, SDS-PAGE Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Rattus norvegicus