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Literature summary for 1.1.1.149 extracted from

  • Endo, S.; Arai, Y.; Hara, A.; Kitade, Y.; Bunai, Y.; El-Kabbani, O.; Matsunaga, T.
    Substrate specificity and inhibitor sensitivity of rabbit 20alpha-hydroxysteroid dehydrogenase (2013), Biol. Pharm. Bull., 36, 1514-1518.
    View publication on PubMed
Search for more literature for 1.1.1.149

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21(DE3) cells Oryctolagus cuniculus

Inhibitors

Inhibitors Comment Organism Structure
3',3'',5',5''-tetrabromophenolphthalein
-
 Oryctolagus cuniculus
benzbromarone
-
 Oryctolagus cuniculus
Flufenamic acid
-
 Oryctolagus cuniculus
galangin
-
 Oryctolagus cuniculus
Hexestrol
-
 Oryctolagus cuniculus
kaempferol potent and competitive inhibitor Oryctolagus cuniculus
Mefenamic acid
-
 Oryctolagus cuniculus
myricetin
-
 Oryctolagus cuniculus
naringenin
-
 Oryctolagus cuniculus
Phenolphthalein
-
 Oryctolagus cuniculus
quercetin potent and competitive inhibitor Oryctolagus cuniculus
Sulfobromophthalein
-
 Oryctolagus cuniculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0005
-
 5alpha-pregnan-3,20-dione at pH 7.4 and 37°C Oryctolagus cuniculus
0.0006
-
 progesterone at pH 7.4 and 37°C Oryctolagus cuniculus
0.0006
-
 isatin at pH 7.4 and 37°C Oryctolagus cuniculus
0.0008
-
 5alpha-pregnan-3alpha,20alpha-diol at pH 7.4 and 37°C Oryctolagus cuniculus
0.0009
-
 Nonanal at pH 7.4 and 37°C Oryctolagus cuniculus
0.001
-
 4-androstene-3,17-dione at pH 7.4 and 37°C Oryctolagus cuniculus
0.001
-
 5beta-pregnan-3,20-dione at pH 7.4 and 37°C Oryctolagus cuniculus
0.001
-
 5beta-Pregnan-3alpha-ol-20-one at pH 7.4 and 37°C Oryctolagus cuniculus
0.001
-
 4-pregnen-3alpha-ol-20-one at pH 7.4 and 37°C Oryctolagus cuniculus
0.001
-
 2-tert-butyl-1,4-benzoquinone at pH 7.4 and 37°C Oryctolagus cuniculus
0.0011
-
 estrone at pH 7.4 and 37°C Oryctolagus cuniculus
0.0012
-
 4-Nitroacetophenone at pH 7.4 and 37°C Oryctolagus cuniculus
0.0013
-
 17beta-estradiol at pH 7.4 and 37°C Oryctolagus cuniculus
0.0013
-
 5alpha-pregnan-3alpha-ol-20-one at pH 7.4 and 37°C Oryctolagus cuniculus
0.0014
-
 5beta-Androstan-3alpha,17beta-diol at pH 7.4 and 37°C Oryctolagus cuniculus
0.0017
-
 5beta-Androstan-3alpha-ol-17-one at pH 7.4 and 37°C Oryctolagus cuniculus
0.0018
-
 4-oxo-2-nonenal at pH 7.4 and 37°C Oryctolagus cuniculus
0.002
-
 6-tert-butyl-2,3-epoxy-5-cyclohexen-1,4-dione at pH 7.4 and 37°C Oryctolagus cuniculus
0.0022
-
 20alpha-hydroxyprogesterone at pH 7.4 and 37°C Oryctolagus cuniculus
0.0022
-
 5alpha-androstan-3beta,17beta-diol at pH 7.4 and 37°C Oryctolagus cuniculus
0.0025
-
 5beta-Androstan-3beta,17beta-diol at pH 7.4 and 37°C Oryctolagus cuniculus
0.0026
-
 5beta-Pregnan-3alpha,21-diol-20-one at pH 7.4 and 37°C Oryctolagus cuniculus
0.0028
-
 5beta-androstan-3beta-ol-17-one at pH 7.4 and 37°C Oryctolagus cuniculus
0.0029
-
 7alpha-hydroxy-dehydroepiandrosterone at pH 7.4 and 37°C Oryctolagus cuniculus
0.0031
-
 5-androstene-3beta,17beta-diol at pH 7.4 and 37°C Oryctolagus cuniculus
0.0034
-
 5alpha-dihydrotestosterone at pH 7.4 and 37°C Oryctolagus cuniculus
0.0041
-
 5alpha-Androstan-3alpha-ol-17-one at pH 7.4 and 37°C Oryctolagus cuniculus
0.0042
-
 dehydroepiandrosterone 3-sulfate at pH 7.4 and 37°C Oryctolagus cuniculus
0.0042
-
 5alpha-androstan-3alpha,17beta-diol at pH 7.4 and 37°C Oryctolagus cuniculus
0.0053
-
 4-hydroxy-2-nonenal at pH 7.4 and 37°C Oryctolagus cuniculus
0.0055
-
 trans-2-nonenal at pH 7.4 and 37°C Oryctolagus cuniculus
0.0057
-
 5beta-pregnan-20alpha-ol-3-one at pH 7.4 and 37°C Oryctolagus cuniculus
0.0059
-
 5alpha-pregnan-20alpha-ol-3-one at pH 7.4 and 37°C Oryctolagus cuniculus
0.0059
-
 4-oxo-2-hexenal at pH 7.4 and 37°C Oryctolagus cuniculus
0.006
-
 dehydroepiandrosterone at pH 7.4 and 37°C Oryctolagus cuniculus
0.006
-
 5alpha-Androstan-3beta-ol-17-one at pH 7.4 and 37°C Oryctolagus cuniculus
0.0062
-
 5beta-androstan-17beta-ol-3-one at pH 7.4 and 37°C Oryctolagus cuniculus
0.0062
-
 5alpha-Pregnan-3alpha,21-diol-20-one at pH 7.4 and 37°C Oryctolagus cuniculus
0.0067
-
 Estrone 3-sulfate at pH 7.4 and 37°C Oryctolagus cuniculus
0.0074
-
 trans-2-hexenal at pH 7.4 and 37°C Oryctolagus cuniculus
0.0076
-
 hexanal at pH 7.4 and 37°C Oryctolagus cuniculus
0.0078
-
 5beta-pregnan-3alpha,20alpha-diol at pH 7.4 and 37°C Oryctolagus cuniculus
0.0089
-
 all-trans-retinal at pH 7.4 and 37°C Oryctolagus cuniculus
0.011
-
 5alpha-pregnan-20alpha-ol-3-one at pH 7.4 and 37°C Oryctolagus cuniculus
0.013
-
 testosterone at pH 7.4 and 37°C Oryctolagus cuniculus
0.014
-
 acrolein at pH 7.4 and 37°C Oryctolagus cuniculus
0.018
-
 menadione at pH 7.4 and 37°C Oryctolagus cuniculus
0.018
-
 5alpha-dihydrotestosterone at pH 7.4 and 37°C Oryctolagus cuniculus
0.018
-
 beta-ionol at pH 7.4 and 37°C Oryctolagus cuniculus
0.019
-
 diacetyl at pH 7.4 and 37°C Oryctolagus cuniculus
0.034
-
 befunolol at pH 7.4 and 37°C Oryctolagus cuniculus
0.053
-
 alpha-tetralone at pH 7.4 and 37°C Oryctolagus cuniculus
0.061
-
 pyridine 3-aldehyde at pH 7.4 and 37°C Oryctolagus cuniculus
0.068
-
 isocaproaldehyde at pH 7.4 and 37°C Oryctolagus cuniculus
0.088
-
 methylglyoxal at pH 7.4 and 37°C Oryctolagus cuniculus
0.111
-
 ketotifen at pH 7.4 and 37°C Oryctolagus cuniculus
0.112
-
 (S)-1-tetralol at pH 7.4 and 37°C Oryctolagus cuniculus
0.131
-
 (S)-1-indanol at pH 7.4 and 37°C Oryctolagus cuniculus
0.152
-
 4-chromanol at pH 7.4 and 37°C Oryctolagus cuniculus
0.162
-
 acetoin at pH 7.4 and 37°C Oryctolagus cuniculus
0.18
-
 geraniol at pH 7.4 and 37°C Oryctolagus cuniculus
0.26
-
 trans-benzene dihydrodiol at pH 7.4 and 37°C Oryctolagus cuniculus
1.4
-
 3-deoxyglucosone at pH 7.4 and 37°C Oryctolagus cuniculus

Organism

Organism UniProt Comment Textmining
Oryctolagus cuniculus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
Sepharose 6FF resin column chromatography Oryctolagus cuniculus

Source Tissue

Source Tissue Comment Organism Textmining
ovary
-
 Oryctolagus cuniculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(S)-1-indanol + NADP+
-
 Oryctolagus cuniculus ?
-
 ?
(S)-1-tetralol + NADP+
-
 Oryctolagus cuniculus ?
-
 ?
17beta-estradiol + NADP+
-
 Oryctolagus cuniculus ?
-
 ?
2-tert-butyl-1,4-benzoquinone + NADPH + H+
-
 Oryctolagus cuniculus ?
-
 ?
20alpha-hydroxyprogesterone + NADP+
-
 Oryctolagus cuniculus ?
-
 ?
3-deoxyglucosone + NADPH + H+
-
 Oryctolagus cuniculus ?
-
 ?
4-androstene-3,17-dione + NADPH + H+
-
 Oryctolagus cuniculus ?
-
 ?
4-chromanol + NADP+
-
 Oryctolagus cuniculus ?
-
 ?
4-hydroxy-2-nonenal + NADPH + H+
-
 Oryctolagus cuniculus ?
-
 ?
4-nitroacetophenone + NADPH + H+
-
 Oryctolagus cuniculus ?
-
 ?
4-oxo-2-hexenal + NADPH + H+
-
 Oryctolagus cuniculus ?
-
 ?
4-oxo-2-nonenal + NADPH + H+
-
 Oryctolagus cuniculus ?
-
 ?
4-pregnen-3alpha-ol-20-one + NADPH + H+
-
 Oryctolagus cuniculus ?
-
 ?
5-androstene-3beta,17beta-diol + NADP+
-
 Oryctolagus cuniculus ?
-
 ?
5alpha-androstan-3alpha,17beta-diol + NADP+
-
 Oryctolagus cuniculus ?
-
 ?
5alpha-androstan-3alpha-ol-17-one + NADPH + H+
-
 Oryctolagus cuniculus ?
-
 ?
5alpha-androstan-3beta,17beta-diol + NADP+
-
 Oryctolagus cuniculus ?
-
 ?
5alpha-androstan-3beta-ol-17-one + NADPH + H+
-
 Oryctolagus cuniculus ?
-
 ?
5alpha-dihydrotestosterone + NADP+
-
 Oryctolagus cuniculus ?
-
 ?
5alpha-dihydrotestosterone + NADPH + H+
-
 Oryctolagus cuniculus ?
-
 ?
5alpha-pregnan-20alpha-ol-3-one + NADP+
-
 Oryctolagus cuniculus 5beta-pregnan-3,20-dione + NADPH + H+
-
 r
5alpha-pregnan-20alpha-ol-3-one + NADP+
-
 Oryctolagus cuniculus ?
-
 ?
5alpha-pregnan-3,20-dione + NADPH + H+
-
 Oryctolagus cuniculus ?
-
 ?
5alpha-pregnan-3alpha,20alpha-diol + NADP+
-
 Oryctolagus cuniculus ?
-
 ?
5alpha-pregnan-3alpha,21-diol-20-one + NADPH + H+
-
 Oryctolagus cuniculus ?
-
 ?
5alpha-pregnan-3alpha-ol-20-one + NADPH + H+
-
 Oryctolagus cuniculus ?
-
 ?
5beta-androstan-17beta-ol-3-one + NADP+
-
 Oryctolagus cuniculus ?
-
 ?
5beta-androstan-3alpha,17beta-diol + NADP+
-
 Oryctolagus cuniculus ?
-
 ?
5beta-androstan-3alpha-ol-17-one + NADPH + H+
-
 Oryctolagus cuniculus ?
-
 ?
5beta-androstan-3beta,17beta-diol + NADP+
-
 Oryctolagus cuniculus ?
-
 ?
5beta-androstan-3beta-ol-17-one + NADPH + H+
-
 Oryctolagus cuniculus ?
-
 ?
5beta-pregnan-20alpha-ol-3-one + NADP+
-
 Oryctolagus cuniculus ?
-
 ?
5beta-pregnan-3,20-dione + NADPH + H+
-
 Oryctolagus cuniculus 5alpha-pregnan-20alpha-ol-3-one + NADP+
-
 r
5beta-pregnan-3alpha,20alpha-diol + NADP+
-
 Oryctolagus cuniculus ?
-
 ?
5beta-pregnan-3alpha,21-diol-20-one + NADPH + H+
-
 Oryctolagus cuniculus ?
-
 ?
5beta-pregnan-3alpha-ol-20-one + NADPH + H+
-
 Oryctolagus cuniculus ?
-
 ?
6-tert-butyl-2,3-epoxy-5-cyclohexen-1,4-dione + NADPH + H+
-
 Oryctolagus cuniculus ?
-
 ?
7alpha-hydroxy-dehydroepiandrosterone + NADPH + H+
-
 Oryctolagus cuniculus ?
-
 ?
acetoin + NADPH + H+
-
 Oryctolagus cuniculus ?
-
 ?
acrolein + NADPH + H+
-
 Oryctolagus cuniculus ?
-
 ?
all-trans-retinal + NADPH + H+
-
 Oryctolagus cuniculus ?
-
 ?
alpha-tetralone + NADPH + H+
-
 Oryctolagus cuniculus ?
-
 ?
befunolol + NADPH + H+
-
 Oryctolagus cuniculus ?
-
 ?
beta-ionol + NADP+
-
 Oryctolagus cuniculus ?
-
 ?
dehydroepiandrosterone + NADPH + H+
-
 Oryctolagus cuniculus ?
-
 ?
dehydroepiandrosterone 3-sulfate + NADPH + H+
-
 Oryctolagus cuniculus ?
-
 ?
diacetyl + NADPH + H+
-
 Oryctolagus cuniculus ?
-
 ?
estrone + NADPH + H+
-
 Oryctolagus cuniculus ?
-
 ?
estrone 3-sulfate + NADPH + H+
-
 Oryctolagus cuniculus ?
-
 ?
geraniol + NADP+
-
 Oryctolagus cuniculus ?
-
 ?
hexanal + NADPH + H+
-
 Oryctolagus cuniculus ?
-
 ?
isatin + NADP+
-
 Oryctolagus cuniculus ?
-
 ?
isocaproaldehyde + NADPH + H+
-
 Oryctolagus cuniculus ?
-
 ?
ketotifen + NADPH + H+
-
 Oryctolagus cuniculus ?
-
 ?
menadione + NADPH + H+
-
 Oryctolagus cuniculus ?
-
 ?
methylglyoxal + NADPH + H+
-
 Oryctolagus cuniculus ?
-
 ?
additional information no activity with 5beta-androstan-17beta-ol-3-one, 5beta-pregnan-20alpha-ol-3-one, testosterone and 20alpha-hydroxy progesterone Oryctolagus cuniculus ?
-
 ?
nonanal + NADPH + H+
-
 Oryctolagus cuniculus ?
-
 ?
progesterone + NADPH + H+
-
 Oryctolagus cuniculus 20alpha-hydroxyprogesterone + NADP+
-
 ?
pyridine 3-aldehyde + NADPH + H+
-
 Oryctolagus cuniculus ?
-
 ?
testosterone + NADP+
-
 Oryctolagus cuniculus ?
-
 ?
trans-2-hexenal + NADPH + H+
-
 Oryctolagus cuniculus ?
-
 ?
trans-2-nonenal + NADPH + H+
-
 Oryctolagus cuniculus ?
-
 ?
trans-benzene dihydrodiol + NADP+
-
 Oryctolagus cuniculus ?
-
 ?

Synonyms

Synonyms Comment Organism
20alpha-HSD
-
 Oryctolagus cuniculus
AKR1C5
-
 Oryctolagus cuniculus

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.0085
-
 all-trans-retinal at pH 7.4 and 37°C Oryctolagus cuniculus
0.009
-
 4-hydroxy-2-nonenal at pH 7.4 and 37°C Oryctolagus cuniculus
0.011
-
 17beta-estradiol at pH 7.4 and 37°C Oryctolagus cuniculus
0.0115
-
 4-oxo-2-hexenal at pH 7.4 and 37°C Oryctolagus cuniculus
0.017
-
 estrone at pH 7.4 and 37°C Oryctolagus cuniculus
0.017
-
 5beta-Pregnan-3alpha,21-diol-20-one at pH 7.4 and 37°C Oryctolagus cuniculus
0.018
-
 5alpha-pregnan-3,20-dione at pH 7.4 and 37°C Oryctolagus cuniculus
0.018
-
 5alpha-Pregnan-3alpha,21-diol-20-one at pH 7.4 and 37°C Oryctolagus cuniculus
0.02
-
 trans-2-nonenal at pH 7.4 and 37°C Oryctolagus cuniculus
0.02
-
 ketotifen at pH 7.4 and 37°C Oryctolagus cuniculus
0.023
-
 isocaproaldehyde at pH 7.4 and 37°C Oryctolagus cuniculus
0.025
-
 5alpha-dihydrotestosterone at pH 7.4 and 37°C Oryctolagus cuniculus
0.025
-
 trans-2-hexenal at pH 7.4 and 37°C Oryctolagus cuniculus
0.025
-
 5alpha-pregnan-3alpha,20alpha-diol at pH 7.4 and 37°C Oryctolagus cuniculus
0.027
-
 progesterone at pH 7.4 and 37°C Oryctolagus cuniculus
0.028
-
 5beta-pregnan-3,20-dione at pH 7.4 and 37°C Oryctolagus cuniculus
0.03
-
 5beta-Pregnan-3alpha-ol-20-one at pH 7.4 and 37°C Oryctolagus cuniculus
0.032
-
 Nonanal at pH 7.4 and 37°C Oryctolagus cuniculus
0.032
-
 5alpha-androstan-3beta,17beta-diol at pH 7.4 and 37°C Oryctolagus cuniculus
0.032
-
 5alpha-pregnan-3alpha-ol-20-one at pH 7.4 and 37°C Oryctolagus cuniculus
0.032
-
 4-pregnen-3alpha-ol-20-one at pH 7.4 and 37°C Oryctolagus cuniculus
0.033
-
 geraniol at pH 7.4 and 37°C Oryctolagus cuniculus
0.033
-
 5beta-Androstan-3beta,17beta-diol at pH 7.4 and 37°C Oryctolagus cuniculus
0.035
-
 acrolein at pH 7.4 and 37°C Oryctolagus cuniculus
0.043
-
 hexanal at pH 7.4 and 37°C Oryctolagus cuniculus
0.043
-
 4-androstene-3,17-dione at pH 7.4 and 37°C Oryctolagus cuniculus
0.043
-
 7alpha-hydroxy-dehydroepiandrosterone at pH 7.4 and 37°C Oryctolagus cuniculus
0.045
-
 5beta-androstan-3beta-ol-17-one at pH 7.4 and 37°C Oryctolagus cuniculus
0.047
-
 5alpha-dihydrotestosterone at pH 7.4 and 37°C Oryctolagus cuniculus
0.048
-
 20alpha-hydroxyprogesterone at pH 7.4 and 37°C Oryctolagus cuniculus
0.053
-
 alpha-tetralone at pH 7.4 and 37°C Oryctolagus cuniculus
0.057
-
 testosterone at pH 7.4 and 37°C Oryctolagus cuniculus
0.067
-
 5beta-Androstan-3alpha-ol-17-one at pH 7.4 and 37°C Oryctolagus cuniculus
0.068
-
 4-chromanol at pH 7.4 and 37°C Oryctolagus cuniculus
0.077
-
 5alpha-pregnan-20alpha-ol-3-one at pH 7.4 and 37°C Oryctolagus cuniculus
0.08
-
 dehydroepiandrosterone 3-sulfate at pH 7.4 and 37°C Oryctolagus cuniculus
0.083
-
 5alpha-Androstan-3beta-ol-17-one at pH 7.4 and 37°C Oryctolagus cuniculus
0.085
-
 5alpha-Androstan-3alpha-ol-17-one at pH 7.4 and 37°C Oryctolagus cuniculus
0.097
-
 acetoin at pH 7.4 and 37°C Oryctolagus cuniculus
0.098
-
 Estrone 3-sulfate at pH 7.4 and 37°C Oryctolagus cuniculus
0.1
-
 5-androstene-3beta,17beta-diol at pH 7.4 and 37°C Oryctolagus cuniculus
0.108
-
 trans-benzene dihydrodiol at pH 7.4 and 37°C Oryctolagus cuniculus
0.112
-
 4-Nitroacetophenone at pH 7.4 and 37°C Oryctolagus cuniculus
0.112
-
 4-oxo-2-nonenal at pH 7.4 and 37°C Oryctolagus cuniculus
0.117
-
 befunolol at pH 7.4 and 37°C Oryctolagus cuniculus
0.12
-
 methylglyoxal at pH 7.4 and 37°C Oryctolagus cuniculus
0.125
-
 menadione at pH 7.4 and 37°C Oryctolagus cuniculus
0.132
-
 pyridine 3-aldehyde at pH 7.4 and 37°C Oryctolagus cuniculus
0.137
-
 isatin at pH 7.4 and 37°C Oryctolagus cuniculus
0.153
-
 5beta-androstan-17beta-ol-3-one at pH 7.4 and 37°C Oryctolagus cuniculus
0.153
-
 5beta-pregnan-20alpha-ol-3-one at pH 7.4 and 37°C Oryctolagus cuniculus
0.155
-
 dehydroepiandrosterone at pH 7.4 and 37°C Oryctolagus cuniculus
0.158
-
 diacetyl at pH 7.4 and 37°C Oryctolagus cuniculus
0.158
-
 5alpha-pregnan-20alpha-ol-3-one at pH 7.4 and 37°C Oryctolagus cuniculus
0.167
-
 6-tert-butyl-2,3-epoxy-5-cyclohexen-1,4-dione at pH 7.4 and 37°C Oryctolagus cuniculus
0.183
-
 3-deoxyglucosone at pH 7.4 and 37°C Oryctolagus cuniculus
0.183
-
 2-tert-butyl-1,4-benzoquinone at pH 7.4 and 37°C Oryctolagus cuniculus
0.2
-
 (S)-1-indanol at pH 7.4 and 37°C Oryctolagus cuniculus
0.217
-
 (S)-1-tetralol at pH 7.4 and 37°C Oryctolagus cuniculus
0.233
-
 beta-ionol at pH 7.4 and 37°C Oryctolagus cuniculus
0.25
-
 5beta-Androstan-3alpha,17beta-diol at pH 7.4 and 37°C Oryctolagus cuniculus
0.27
-
 5alpha-androstan-3alpha,17beta-diol at pH 7.4 and 37°C Oryctolagus cuniculus
0.283
-
 5beta-pregnan-3alpha,20alpha-diol at pH 7.4 and 37°C Oryctolagus cuniculus

Cofactor

Cofactor Comment Organism Structure
NADH
-
 Oryctolagus cuniculus
NADPH
-
 Oryctolagus cuniculus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000022
-
 at pH 7.4 and 37°C Oryctolagus cuniculus Phenolphthalein
0.000059
-
 at pH 7.4 and 37°C Oryctolagus cuniculus quercetin
0.00011
-
 at pH 7.4 and 37°C Oryctolagus cuniculus kaempferol
0.00012
-
 at pH 7.4 and 37°C Oryctolagus cuniculus benzbromarone
0.00037
-
 at pH 7.4 and 37°C Oryctolagus cuniculus naringenin
0.00041
-
 at pH 7.4 and 37°C Oryctolagus cuniculus galangin
0.00064
-
 at pH 7.4 and 37°C Oryctolagus cuniculus myricetin
0.003
-
 at pH 7.4 and 37°C Oryctolagus cuniculus 3',3'',5',5''-tetrabromophenolphthalein
0.0064
-
 at pH 7.4 and 37°C Oryctolagus cuniculus Hexestrol
0.01
-
 at pH 7.4 and 37°C Oryctolagus cuniculus Mefenamic acid
0.011
-
 at pH 7.4 and 37°C Oryctolagus cuniculus Sulfobromophthalein
0.026
-
 at pH 7.4 and 37°C Oryctolagus cuniculus Flufenamic acid

kcat/KM [mM/s]

kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
0.018
-
 geraniol at pH 7.4 and 37°C Oryctolagus cuniculus
0.062
-
 4-oxo-2-nonenal at pH 7.4 and 37°C Oryctolagus cuniculus
0.13
-
 3-deoxyglucosone at pH 7.4 and 37°C Oryctolagus cuniculus
0.18
-
 ketotifen at pH 7.4 and 37°C Oryctolagus cuniculus
0.35
-
 isocaproaldehyde at pH 7.4 and 37°C Oryctolagus cuniculus
0.42
-
 trans-benzene dihydrodiol at pH 7.4 and 37°C Oryctolagus cuniculus
0.45
-
 4-chromanol at pH 7.4 and 37°C Oryctolagus cuniculus
0.95
-
 all-trans-retinal at pH 7.4 and 37°C Oryctolagus cuniculus
1
-
 alpha-tetralone at pH 7.4 and 37°C Oryctolagus cuniculus
1.3
-
 acetoin at pH 7.4 and 37°C Oryctolagus cuniculus
1.3
-
 5alpha-pregnan-20alpha-ol-3-one at pH 7.4 and 37°C Oryctolagus cuniculus
1.4
-
 methylglyoxal at pH 7.4 and 37°C Oryctolagus cuniculus
1.5
-
 (S)-1-indanol at pH 7.4 and 37°C Oryctolagus cuniculus
1.6
-
 4-hydroxy-2-nonenal at pH 7.4 and 37°C Oryctolagus cuniculus
1.8
-
 4-oxo-2-hexenal at pH 7.4 and 37°C Oryctolagus cuniculus
2
-
 menadione at pH 7.4 and 37°C Oryctolagus cuniculus
2
-
 (S)-1-tetralol at pH 7.4 and 37°C Oryctolagus cuniculus
2.2
-
 pyridine 3-aldehyde at pH 7.4 and 37°C Oryctolagus cuniculus
2.5
-
 acrolein at pH 7.4 and 37°C Oryctolagus cuniculus
2.7
-
 5alpha-dihydrotestosterone at pH 7.4 and 37°C Oryctolagus cuniculus
3
-
 5alpha-Pregnan-3alpha,21-diol-20-one at pH 7.4 and 37°C Oryctolagus cuniculus
3.3
-
 trans-2-hexenal at pH 7.4 and 37°C Oryctolagus cuniculus
3.7
-
 trans-2-nonenal at pH 7.4 and 37°C Oryctolagus cuniculus
4.3
-
 testosterone at pH 7.4 and 37°C Oryctolagus cuniculus
5.7
-
 hexanal at pH 7.4 and 37°C Oryctolagus cuniculus
6.3
-
 5beta-Pregnan-3alpha,21-diol-20-one at pH 7.4 and 37°C Oryctolagus cuniculus
7.3
-
 5alpha-dihydrotestosterone at pH 7.4 and 37°C Oryctolagus cuniculus
8.3
-
 diacetyl at pH 7.4 and 37°C Oryctolagus cuniculus
8.7
-
 17beta-estradiol at pH 7.4 and 37°C Oryctolagus cuniculus
10.1
-
 beta-ionol at pH 7.4 and 37°C Oryctolagus cuniculus
13.2
-
 befunolol at pH 7.4 and 37°C Oryctolagus cuniculus
13.3
-
 5beta-Androstan-3beta,17beta-diol at pH 7.4 and 37°C Oryctolagus cuniculus
13.8
-
 5alpha-Androstan-3beta-ol-17-one at pH 7.4 and 37°C Oryctolagus cuniculus
14.3
-
 5alpha-androstan-3beta,17beta-diol at pH 7.4 and 37°C Oryctolagus cuniculus
14.3
-
 5alpha-pregnan-20alpha-ol-3-one at pH 7.4 and 37°C Oryctolagus cuniculus
14.7
-
 Estrone 3-sulfate at pH 7.4 and 37°C Oryctolagus cuniculus
15
-
 7alpha-hydroxy-dehydroepiandrosterone at pH 7.4 and 37°C Oryctolagus cuniculus
15.1
-
 estrone at pH 7.4 and 37°C Oryctolagus cuniculus
16
-
 5beta-androstan-3beta-ol-17-one at pH 7.4 and 37°C Oryctolagus cuniculus
18.3
-
 dehydroepiandrosterone 3-sulfate at pH 7.4 and 37°C Oryctolagus cuniculus
20
-
 5alpha-Androstan-3alpha-ol-17-one at pH 7.4 and 37°C Oryctolagus cuniculus
21.7
-
 20alpha-hydroxyprogesterone at pH 7.4 and 37°C Oryctolagus cuniculus
25
-
 5beta-androstan-17beta-ol-3-one at pH 7.4 and 37°C Oryctolagus cuniculus
25
-
 5alpha-pregnan-3alpha-ol-20-one at pH 7.4 and 37°C Oryctolagus cuniculus
26.7
-
 dehydroepiandrosterone at pH 7.4 and 37°C Oryctolagus cuniculus
26.7
-
 5beta-pregnan-20alpha-ol-3-one at pH 7.4 and 37°C Oryctolagus cuniculus
28.3
-
 5beta-pregnan-3,20-dione at pH 7.4 and 37°C Oryctolagus cuniculus
30
-
 5beta-Pregnan-3alpha-ol-20-one at pH 7.4 and 37°C Oryctolagus cuniculus
30
-
 5alpha-pregnan-3alpha,20alpha-diol at pH 7.4 and 37°C Oryctolagus cuniculus
31.7
-
 5-androstene-3beta,17beta-diol at pH 7.4 and 37°C Oryctolagus cuniculus
31.7
-
 4-pregnen-3alpha-ol-20-one at pH 7.4 and 37°C Oryctolagus cuniculus
35
-
 Nonanal at pH 7.4 and 37°C Oryctolagus cuniculus
36.7
-
 5alpha-pregnan-3,20-dione at pH 7.4 and 37°C Oryctolagus cuniculus
36.7
-
 5beta-pregnan-3alpha,20alpha-diol at pH 7.4 and 37°C Oryctolagus cuniculus
40
-
 5beta-Androstan-3alpha-ol-17-one at pH 7.4 and 37°C Oryctolagus cuniculus
43.3
-
 4-androstene-3,17-dione at pH 7.4 and 37°C Oryctolagus cuniculus
45
-
 progesterone at pH 7.4 and 37°C Oryctolagus cuniculus
63.3
-
 5alpha-androstan-3alpha,17beta-diol at pH 7.4 and 37°C Oryctolagus cuniculus
83.3
-
 6-tert-butyl-2,3-epoxy-5-cyclohexen-1,4-dione at pH 7.4 and 37°C Oryctolagus cuniculus
93.3
-
 4-Nitroacetophenone at pH 7.4 and 37°C Oryctolagus cuniculus
183.3
-
 5beta-Androstan-3alpha,17beta-diol at pH 7.4 and 37°C Oryctolagus cuniculus
183.3
-
 2-tert-butyl-1,4-benzoquinone at pH 7.4 and 37°C Oryctolagus cuniculus
233.3
-
 isatin at pH 7.4 and 37°C Oryctolagus cuniculus