Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.1.1.149 extracted from

  • Blanchette, S.; Blouin, K.; Richard, C.; Dupont, P.; Luu-The, V.; Tchernof, A.
    Expression and activity of 20alpha-hydroxysteroid dehydrogenase (AKR1C1) in abdominal subcutaneous and omental adipose tissue in women (2005), J. Clin. Endocrinol. Metab., 90, 264-270.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
17alpha-hydroxyprogesterone + NAD(P)H Homo sapiens the enzyme activity is highest in women with visceral obesity 17alpha,20alpha-dihydroxypregn-4-en-3-one + NAD(P)+
-
r

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
women about 47 years old and with body mass index of about 27
-

Source Tissue

Source Tissue Comment Organism Textmining
adipose tissue abdominal subcutaneous and omental adipose tissue, the enzyme activity is highest in women with visceral obesity, expression analysis Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
17alpha-hydroxyprogesterone + NAD(P)H
-
Homo sapiens 17alpha,20alpha-dihydroxypregn-4-en-3-one + NAD(P)+
-
r
17alpha-hydroxyprogesterone + NAD(P)H the enzyme activity is highest in women with visceral obesity Homo sapiens 17alpha,20alpha-dihydroxypregn-4-en-3-one + NAD(P)+
-
r

Synonyms

Synonyms Comment Organism
AKR1C1
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NAD(P)+
-
Homo sapiens
NAD(P)H
-
Homo sapiens