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Literature summary for 1.1.1.149 extracted from

  • Strickler, R.C.; Tobias, B.; Covey, D.F.
    Human placental 17beta-estradiol dehydrogenase and 20alpha-hydroxysteroid dehydrogenase. Two activities at a single enzyme active site (1981), J. Biol. Chem., 256, 316-321.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
16alpha-Bromoacetoxyprogesterone
-
Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.2
-
progesterone
-
Homo sapiens
2.5
-
20alpha-hydroxyprogesterone
-
Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
35000
-
1 * 35000, SDS-PAGE Homo sapiens
35000
-
2 * 35000, SDS disc gel electrophorese Homo sapiens
68000
-
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
co-purification with 17beta-estradiol dehydrogenase, EC 1.1.1.62, affinity chromatography Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
placenta
-
Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.038 0.046 calculated from 17beta-estadiol dehydrogenase activity Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
progesterone + NAD(P)H
-
Homo sapiens 20alpha-hydroxyprogesterone + NAD(P)+
-
r

Subunits

Subunits Comment Organism
dimer 2 * 35000, SDS disc gel electrophorese Homo sapiens
monomer 1 * 35000, SDS-PAGE Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADP+
-
Homo sapiens
NADPH
-
Homo sapiens