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Literature summary for 1.1.1.146 extracted from
- The 11beta-hydroxysteroid dehydrogenase isoforms pivotal catalytic activities yield potent C11-oxy C19 steroids with 11betaHSD2 favouring 11-ketotestosterone, 11-ketoandrostenedione and 11-ketoprogesterone biosynthesis (2019), J. Steroid Biochem. Mol. Biol., 189, 116-126 .
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in HEK-293 cells | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 11alpha-hydroxyprogesterone | - |
Homo sapiens |  |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.000023 | - |
11beta-hydroxyprogesterone | isoform 11betaHSD2, pH and temperature not specified in the publication | Homo sapiens | |
| 0.000147 | - |
11beta-hydroxytestosterone | isoform 11betaHSD2, pH and temperature not specified in the publication | Homo sapiens | |
| 0.000685 | - |
11beta-hydroxyandrostenedione | isoform 11betaHSD2, pH and temperature not specified in the publication | Homo sapiens | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| cortisol + NAD+ | Homo sapiens | - |
cortisone + NADH + H+ | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P80365 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| LNCaP cell | - |
Homo sapiens | - |
| prostate gland | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 11beta-hydroxy-5alpha-androstane-3,17-dione + NAD+ | - |
Homo sapiens | 11-keto-5alpha-androstane-3,17-dione + NADH + H+ | - |
? | |
| 11beta-hydroxyandrostenedione + NAD+ | - |
Homo sapiens | 11-ketoandrostenedione + NADH + H+ | - |
? | |
| 11beta-hydroxyandrosterone + NAD+ | - |
Homo sapiens | 11-ketoandrosterone + NADH + H+ | - |
? | |
| 11beta-hydroxydihydrotestosterone + NAD+ | - |
Homo sapiens | 11-ketodihydrotestosterone + NADH + H+ | - |
? | |
| 11beta-hydroxyprogesterone + NAD+ | - |
Homo sapiens | 11-ketoprogesterone + NADH + H+ | - |
? | |
| 11beta-hydroxytestosterone + NAD+ | - |
Homo sapiens | 11-ketotestosterone + NADH + H+ | - |
? | |
| 21-deoxycortisol + NAD+ | - |
Homo sapiens | 21-deoxycortisone + NADH + H+ | - |
? | |
| 5alpha-pregnan-11beta,17alpha-diol-3,20-dione + NAD+ | - |
Homo sapiens | 5alpha-pregnan-17alpha-ol-3,11,20-trione + NADH + H+ | - |
? | |
| 5alpha-pregnan-3alpha,11beta,17alpha-triol-20-one + NAD+ | - |
Homo sapiens | 5alpha-pregnan-3alpha,17alpha-diol-11,20-dione + NADH + H+ | - |
? | |
| cortisol + NAD+ | - |
Homo sapiens | cortisone + NADH + H+ | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 11beta-hydroxysteroid dehydrogenase | - |
Homo sapiens |
| 11betaHSD2 | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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