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Literature summary for 1.1.1.146 extracted from

  • Chen, X.; Dong, Y.; Cao, S.; Li, X.; Wang, Z.; Chen, R.; Ge, R.S.
    Effects of polybrominated diphenyl ethers on rat and human 11beta-hydroxysteroid dehydrogenase 1 and 2 activities (2016), Pharmacology, 98, 115-123.
    View publication on PubMed
Search for more literature for 1.1.1.146

Inhibitors

Inhibitors Comment Organism Structure
BDE-100 inhibitor of isoform HSD11B2 Homo sapiens
BDE-153 inhibitor of isoform HSD11B2 Homo sapiens
BDE-3 inhibitor of isoform HSD11B2 Rattus norvegicus
BDE-47 inhibitor of isoform HSD11B2 Rattus norvegicus
additional information isoform HSD11B1 is not inhibited by 4-bromobiphenyl, BDE-3, BDE-47, BDE-100, and BDE-153 Homo sapiens
additional information isoform HSD11B1 is not inhibited by 4-bromobiphenyl, BDE-3, BDE-47, BDE-100, and BDE-153 Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Rattus norvegicus
-
-
-

Synonyms

Synonyms Comment Organism
11beta-hydroxysteroid dehydrogenase
-
 Homo sapiens
11beta-hydroxysteroid dehydrogenase
-
 Rattus norvegicus
HSD11B1 isoform Homo sapiens
HSD11B1 isoform Rattus norvegicus
Hsd11B2 isoform Homo sapiens
Hsd11B2 isoform Rattus norvegicus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00441
-
 pH and temperature not specified in the publication Homo sapiens BDE-153
0.00595
-
 pH and temperature not specified in the publication Rattus norvegicus BDE-47
0.01197
-
 pH and temperature not specified in the publication Homo sapiens BDE-100
0.01242
-
 pH and temperature not specified in the publication Rattus norvegicus BDE-3