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Literature summary for 1.1.1.146 extracted from

  • Coutinho, A.E.; Kipari, T.M.; Zhang, Z.; Esteves, C.L.; Lucas, C.D.; Gilmour, J.S.; Webster, S.P.; Walker, B.R.; Hughes, J.; Savill, J.S.; Seckl, J.R.; Rossi, A.G.; Chapman, K.E.
    11beta-Hydroxysteroid dehydrogenase type 1 is expressed in neutrophils and restrains an inflammatory response in male mice (2016), Endocrinology, 157, 2928-2936.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
UE2316 selective isoform 11beta-HSD1 inhibitor Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cortisone + NADPH + H+ Mus musculus
-
cortisol + NADP+
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
neutrophil
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
11-dehydrocorticosterone + NADPH + H+
-
Mus musculus corticosterone + NADP+
-
?
cortisone + NADPH + H+
-
Mus musculus cortisol + NADP+
-
?

Synonyms

Synonyms Comment Organism
11beta-HSD1
-
Mus musculus
11beta-hydroxysteroid dehydrogenase type 1
-
Mus musculus

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Mus musculus

Expression

Organism Comment Expression
Mus musculus the enzyme is highly expressed in immune cells elicited to the mouse peritoneum during thioglycollate-induced peritonitis up