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Literature summary for 1.1.1.146 extracted from
- Biological roles of hydroxysteroid (11-beta) dehydrogenase 1 (HSD11B1), HSD11B2, and glucocorticoid receptor (NR3C1) in sheep conceptus elongation (2015), Biol. Reprod., 93, 38.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| morpholino antisense oligonucleotide | about 50% inhibition at 0.002 mM; about 50% inhibition at 0.002 mM | Ovis aries |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| cortisol + NADP+ | Ovis aries | - |
cortisone + NADPH + H+ | - |
r |  |
| cortisone + NADPH + H+ | Ovis aries | - |
cortisol + NADP+ | - |
r | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Ovis aries | P50168 | - |
- |
| Ovis aries | P51975 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| conceptus trophectoderm | - |
Ovis aries | - |
| endometrial luminal epithelium | - |
Ovis aries | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| cortisol + NADP+ | - |
Ovis aries | cortisone + NADPH + H+ | - |
r | |
| cortisone + NADPH + H+ | - |
Ovis aries | cortisol + NADP+ | - |
r | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| HSD11B1 | isoform | Ovis aries |
| Hsd11B2 | isoform | Ovis aries |
| hydroxysteroid (11-beta) dehydrogenase | - |
Ovis aries |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADP+ | - |
Ovis aries | |
| NADPH | - |
Ovis aries | |
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Release 2023.1 (January 2023)
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