Cloned (Comment) | Organism |
---|---|
expressed in HEK-293 cells | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
7-oxo-cholesterol | - |
Mus musculus | |
7beta-hydroxycholesterol | - |
Mus musculus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0002 | - |
11-Dehydrocorticosterone | recombinant enzyme, at pH 7.4 and 37°C | Mus musculus | |
0.0013 | - |
11-Dehydrocorticosterone | native enzyme, at pH 7.4 and 37°C | Mus musculus | |
0.00178 | - |
corticosterone | recombinant enzyme, at pH 7.4 and 37°C | Mus musculus | |
0.0042 | - |
corticosterone | native enzyme, at pH 7.4 and 37°C | Mus musculus | |
0.3176 | - |
7beta-hydroxycholesterol | recombinant enzyme, at pH 7.4 and 37°C | Mus musculus | |
1.269 | - |
7-oxo-cholesterol | recombinant enzyme, at pH 7.4 and 37°C | Mus musculus | |
3.5 | - |
7beta-hydroxycholesterol | native enzyme, at pH 7.4 and 37°C | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Mus musculus | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
hepatocyte | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
11-dehydrocorticosterone + NADPH + H+ | - |
Mus musculus | corticosterone + NADP+ | - |
r | |
7-oxo-cholesterol + NADP+ | - |
Mus musculus | 7beta-hydroxycholesterol + NADPH + H+ | - |
r | |
7beta-hydroxycholesterol + NADPH + H+ | - |
Mus musculus | 7-oxo-cholesterol + NADP+ | - |
r | |
corticosterone + NADP+ | - |
Mus musculus | 11-dehydrocorticosterone + NADPH + H+ | - |
r |
Synonyms | Comment | Organism |
---|---|---|
11beta-hydroxysteroid dehydrogenase type 1 | - |
Mus musculus |
11betaHSD1 | - |
Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADP+ | - |
Mus musculus | |
NADPH | - |
Mus musculus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0022 | - |
recombinant enzyme, at pH 7.4 and 37°C | Mus musculus | 7beta-hydroxycholesterol | |
0.0194 | - |
recombinant enzyme, at pH 7.4 and 37°C | Mus musculus | 7-oxo-cholesterol |