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Literature summary for 1.1.1.146 extracted from

  • Mitic, T.; Shave, S.; Semjonous, N.; McNae, I.; Cobice, D.F.; Lavery, G.G.; Webster, S.P.; Hadoke, P.W.; Walker, B.R.; Andrew, R.
    11beta-Hydroxysteroid dehydrogenase type 1 contributes to the balance between 7-keto- and 7-hydroxy-oxysterols in vivo (2013), Biochem. Pharmacol., 86, 146-153.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expressed in HEK-293 cells Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
7-oxo-cholesterol
-
Mus musculus
7beta-hydroxycholesterol
-
Mus musculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0002
-
11-Dehydrocorticosterone recombinant enzyme, at pH 7.4 and 37°C Mus musculus
0.0013
-
11-Dehydrocorticosterone native enzyme, at pH 7.4 and 37°C Mus musculus
0.00178
-
corticosterone recombinant enzyme, at pH 7.4 and 37°C Mus musculus
0.0042
-
corticosterone native enzyme, at pH 7.4 and 37°C Mus musculus
0.3176
-
7beta-hydroxycholesterol recombinant enzyme, at pH 7.4 and 37°C Mus musculus
1.269
-
7-oxo-cholesterol recombinant enzyme, at pH 7.4 and 37°C Mus musculus
3.5
-
7beta-hydroxycholesterol native enzyme, at pH 7.4 and 37°C Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Mus musculus
-
-

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
hepatocyte
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
11-dehydrocorticosterone + NADPH + H+
-
Mus musculus corticosterone + NADP+
-
r
7-oxo-cholesterol + NADP+
-
Mus musculus 7beta-hydroxycholesterol + NADPH + H+
-
r
7beta-hydroxycholesterol + NADPH + H+
-
Mus musculus 7-oxo-cholesterol + NADP+
-
r
corticosterone + NADP+
-
Mus musculus 11-dehydrocorticosterone + NADPH + H+
-
r

Synonyms

Synonyms Comment Organism
11beta-hydroxysteroid dehydrogenase type 1
-
Mus musculus
11betaHSD1
-
Mus musculus

Cofactor

Cofactor Comment Organism Structure
NADP+
-
Mus musculus
NADPH
-
Mus musculus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0022
-
recombinant enzyme, at pH 7.4 and 37°C Mus musculus 7beta-hydroxycholesterol
0.0194
-
recombinant enzyme, at pH 7.4 and 37°C Mus musculus 7-oxo-cholesterol