Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(2R)-N-(5-hydroxytricyclo[3.3.1.13,7]dec-2-yl)-1-[(3-chloro-2-methylphenyl)sulfonyl]piperidine-2-carboxamide | - |
Homo sapiens | |
(2R)-N-(5-hydroxytricyclo[3.3.1.13,7]dec-2-yl)-1-[(3-chloro-2-methylphenyl)sulfonyl]piperidine-2-carboxamide | treatment of BALB/c mice 15, and 60 m per kg dose-dependently decreases the formation of prednisolone, with respective inhibition ratios of 72 and 88%. The concentration of inhibitor in subcutaneous and celiac adipose as well as liver tissue remains high within 1 h after i.v. treatment, whereas the concentration in plasma dramatically decreases 15 min after administration. The inhibitor is also eliminated moderately in adipose and liver tissue over the subsequent 5 h | Mus musculus | |
(2R)-N-(tricyclo[3.3.1.13,7]dec-2-yl)-1-[(3-chloro-2-methylphenyl)sulfonyl]piperidine-2-carboxamide | - |
Homo sapiens | |
(2R)-N-(tricyclo[3.3.1.13,7]dec-2-yl)-1-[(3-chloro-2-methylphenyl)sulfonyl]piperidine-2-carboxamide | - |
Mus musculus | |
(2R)-N-cycloheptyl-1-[(3-chloro-2-methylphenyl)sulfonyl]piperidine-2-carboxamide | - |
Homo sapiens | |
(2R)-N-cycloheptyl-1-[(3-chloro-2-methylphenyl)sulfonyl]piperidine-2-carboxamide | - |
Mus musculus | |
(2R)-N-[(1R,2S,4R)-1,7,7-trimethylbicyclo[2.2.1]hept-2-yl]-1-[(3-chloro-2-methylphenyl)sulfonyl]piperidine-2-carboxamide | - |
Homo sapiens | |
(2R)-N-[(1R,2S,4R)-1,7,7-trimethylbicyclo[2.2.1]hept-2-yl]-1-[(3-chloro-2-methylphenyl)sulfonyl]piperidine-2-carboxamide | - |
Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P28845 | - |
- |
Mus musculus | P50172 | - |
- |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0000012 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | (2R)-N-(5-hydroxytricyclo[3.3.1.13,7]dec-2-yl)-1-[(3-chloro-2-methylphenyl)sulfonyl]piperidine-2-carboxamide | |
0.0000015 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | (2R)-N-(tricyclo[3.3.1.13,7]dec-2-yl)-1-[(3-chloro-2-methylphenyl)sulfonyl]piperidine-2-carboxamide | |
0.0000031 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | (2R)-N-[(1R,2S,4R)-1,7,7-trimethylbicyclo[2.2.1]hept-2-yl]-1-[(3-chloro-2-methylphenyl)sulfonyl]piperidine-2-carboxamide | |
0.0000037 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | (2R)-N-cycloheptyl-1-[(3-chloro-2-methylphenyl)sulfonyl]piperidine-2-carboxamide | |
0.000013 | - |
pH not specified in the publication, temperature not specified in the publication | Mus musculus | (2R)-N-(tricyclo[3.3.1.13,7]dec-2-yl)-1-[(3-chloro-2-methylphenyl)sulfonyl]piperidine-2-carboxamide | |
0.000015 | - |
pH not specified in the publication, temperature not specified in the publication | Mus musculus | (2R)-N-(5-hydroxytricyclo[3.3.1.13,7]dec-2-yl)-1-[(3-chloro-2-methylphenyl)sulfonyl]piperidine-2-carboxamide | |
0.000024 | - |
pH not specified in the publication, temperature not specified in the publication | Mus musculus | (2R)-N-[(1R,2S,4R)-1,7,7-trimethylbicyclo[2.2.1]hept-2-yl]-1-[(3-chloro-2-methylphenyl)sulfonyl]piperidine-2-carboxamide | |
0.000032 | - |
pH not specified in the publication, temperature not specified in the publication | Mus musculus | (2R)-N-cycloheptyl-1-[(3-chloro-2-methylphenyl)sulfonyl]piperidine-2-carboxamide |