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Literature summary for 1.1.1.146 extracted from

  • Torres-Piedra, M.; Ortiz-Andrade, R.; Villalobos-Molina, R.; Singh, N.; Medina-Franco, J.L.; Webster, S.P.; Binnie, M.; Navarrete-Vazquez, G.; Estrada-Soto, S.
    A comparative study of flavonoid analogues on streptozotocin-nicotinamide induced diabetic rats: quercetin as a potential antidiabetic agent acting via 11beta-hydroxysteroid dehydrogenase type 1 inhibition (2010), Eur. J. Med. Chem., 45, 2606-2612.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expressed in HEK-293 cell Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
flavone
-
Homo sapiens
quercetin
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P28845
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cortisone + NADPH + H+
-
Homo sapiens cortisol + NADP+
-
?

Synonyms

Synonyms Comment Organism
11-beta-hydroxysteroid dehydrogenase type1
-
Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
additional information
-
16% inhibition at 0.01 mM, cell-based assay, pH not specified in the publication, 37°C Homo sapiens flavone
additional information
-
27% inhibition at 0.01 mM, cell-based assay, pH not specified in the publication, 37°C Homo sapiens quercetin