Literature summary for 1.1.1.146 extracted from

Feng, Y.; Huang, S.L.; Dou, W.; Zhang, S.; Chen, J.H.; Shen, Y.; Shen, J.H.; Leng, Y.
Emodin, a natural product, selectively inhibits 11beta-hydroxysteroid dehydrogenase type 1 and ameliorates metabolic disorder in diet-induced obese mice (2010), Br. J. Pharmacol., 161, 113-126.

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Cloned(Commentary)

Cloned (Comment)	Organism
expressed in HEK-293 cell	Mus musculus
expressed in HEK-293 cell	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
3-methylchrysazin	-	Homo sapiens
3-methylchrysazin	-	Mus musculus
Aloe-emodin	-	Homo sapiens
Aloe-emodin	-	Mus musculus
emodin	-	Homo sapiens
emodin	-	Mus musculus
Rhein	-	Mus musculus
rheochrysidin	-	Homo sapiens
rheochrysidin	-	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P28845	-	-
Mus musculus	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Mus musculus
-	Homo sapiens

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
cortisone + NADPH + H+	-	Mus musculus	cortisol + NADP+	-	?
cortisone + NADPH + H+	-	Homo sapiens	cortisol + NADP+	-	?

Synonyms

Synonyms	Comment	Organism
11beta-hydroxysteroid dehydrogenase type 1	-	Mus musculus
11beta-hydroxysteroid dehydrogenase type 1	-	Homo sapiens

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.000081	-	pH 7.4, 37°C	Mus musculus	rheochrysidin
0.000086	-	pH 7.4, 37°C	Mus musculus	emodin
0.000098	-	pH 7.4, 37°C	Mus musculus	Aloe-emodin
0.000186	-	pH 7.4, 37°C	Homo sapiens	emodin
0.0004	-	pH 7.4, 37°C	Mus musculus	3-methylchrysazin
0.000542	-	pH 7.4, 37°C	Homo sapiens	rheochrysidin
0.000879	-	pH 7.4, 37°C	Homo sapiens	Aloe-emodin
0.00284	-	pH 7.4, 37°C	Mus musculus	Rhein
0.00354	-	pH 7.4, 37°C	Homo sapiens	3-methylchrysazin

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Release 2023.1 (January 2023)