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Literature summary for 1.1.1.146 extracted from

  • Zhang, X.; Zhou, Z.; Yang, H.; Chen, J.; Feng, Y.; Du, L.; Leng, Y.; Shen, J.
    4-(Phenylsulfonamidomethyl)benzamides as potent and selective inhibitors of the 11beta-hydroxysteroid dehydrogenase type 1 with efficacy in diabetic ob/ob mice (2009), Bioorg. Med. Chem. Lett., 19, 4455-4458.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
2-chloro-N-(4-[[(2R,6S)-2,6-dimethylmorpholin-4-yl]carbonyl]benzyl)benzenesulfonamide
-
Homo sapiens
2-chloro-N-(4-[[(2R,6S)-2,6-dimethylmorpholin-4-yl]carbonyl]benzyl)benzenesulfonamide
-
Mus musculus
3-chloro-N-(4-[[(2R,6S)-2,6-dimethylmorpholin-4-yl]carbonyl]benzyl)-4-fluorobenzenesulfonamide
-
Homo sapiens
3-chloro-N-(4-[[(2R,6S)-2,6-dimethylmorpholin-4-yl]carbonyl]benzyl)-4-fluorobenzenesulfonamide
-
Mus musculus
3-chloro-N-(4-[[(2R,6S)-2,6-dimethylmorpholin-4-yl]carbonyl]benzyl)benzenesulfonamide
-
Homo sapiens
3-chloro-N-(4-[[(2R,6S)-2,6-dimethylmorpholin-4-yl]carbonyl]benzyl)benzenesulfonamide
-
Mus musculus
3-chloro-N-[4-(morpholin-4-ylcarbonyl)benzyl]benzenesulfonamide
-
Homo sapiens
3-chloro-N-[4-(morpholin-4-ylcarbonyl)benzyl]benzenesulfonamide
-
Mus musculus
3-chloro-N-[4-(piperidin-1-ylcarbonyl)benzyl]benzenesulfonamide
-
Homo sapiens
3-chloro-N-[4-(piperidin-1-ylcarbonyl)benzyl]benzenesulfonamide
-
Mus musculus
3-chloro-N-[4-(pyrrolidin-1-ylcarbonyl)benzyl]benzenesulfonamide
-
Homo sapiens
3-chloro-N-[4-(pyrrolidin-1-ylcarbonyl)benzyl]benzenesulfonamide
-
Mus musculus
3-chloro-N-[4-[(4-methylpiperazin-1-yl)carbonyl]benzyl]benzenesulfonamide
-
Homo sapiens
3-chloro-N-[4-[(4-methylpiperazin-1-yl)carbonyl]benzyl]benzenesulfonamide
-
Mus musculus
4-([[(3-chlorophenyl)sulfonyl]amino]methyl)-N,N-diethylbenzamide
-
Homo sapiens
4-([[(3-chlorophenyl)sulfonyl]amino]methyl)-N,N-diethylbenzamide
-
Mus musculus
4-([[(3-chlorophenyl)sulfonyl]amino]methyl)-N-(tricyclo[3.3.1.13,7]dec-1-yl)benzamide
-
Homo sapiens
4-([[(3-chlorophenyl)sulfonyl]amino]methyl)-N-(tricyclo[3.3.1.13,7]dec-1-yl)benzamide
-
Mus musculus
4-([[(3-chlorophenyl)sulfonyl]amino]methyl)-N-cycloheptyl-N-methylbenzamide
-
Homo sapiens
4-([[(3-chlorophenyl)sulfonyl]amino]methyl)-N-cycloheptyl-N-methylbenzamide
-
Mus musculus
4-([[(3-chlorophenyl)sulfonyl]amino]methyl)-N-cycloheptyl-N-propylbenzamide
-
Homo sapiens
4-([[(3-chlorophenyl)sulfonyl]amino]methyl)-N-cycloheptyl-N-propylbenzamide
-
Mus musculus
4-([[(3-chlorophenyl)sulfonyl]amino]methyl)-N-cycloheptylbenzamide
-
Homo sapiens
4-([[(3-chlorophenyl)sulfonyl]amino]methyl)-N-cycloheptylbenzamide
-
Mus musculus
4-([[(3-chlorophenyl)sulfonyl]amino]methyl)-N-cyclohexylbenzamide
-
Homo sapiens
4-([[(3-chlorophenyl)sulfonyl]amino]methyl)-N-cyclohexylbenzamide
-
Mus musculus
4-([[(3-chlorophenyl)sulfonyl]amino]methyl)-N-cyclopentylbenzamide
-
Homo sapiens
4-([[(3-chlorophenyl)sulfonyl]amino]methyl)-N-cyclopentylbenzamide
-
Mus musculus
4-chloro-N-(4-[[(2R,6S)-2,6-dimethylmorpholin-4-yl]carbonyl]benzyl)benzenesulfonamide
-
Homo sapiens
4-chloro-N-(4-[[(2R,6S)-2,6-dimethylmorpholin-4-yl]carbonyl]benzyl)benzenesulfonamide
-
Mus musculus
glycyrrhizic acid
-
Homo sapiens
glycyrrhizic acid
-
Mus musculus
N-(4-[[(2R,6S)-2,6-dimethylmorpholin-4-yl]carbonyl]benzyl)-3-(trifluoromethyl)benzenesulfonamide
-
Homo sapiens
N-(4-[[(2R,6S)-2,6-dimethylmorpholin-4-yl]carbonyl]benzyl)-3-(trifluoromethyl)benzenesulfonamide
-
Mus musculus
N-butyl-4-([[(3-chlorophenyl)sulfonyl]amino]methyl)-N-cycloheptylbenzamide
-
Homo sapiens
N-butyl-4-([[(3-chlorophenyl)sulfonyl]amino]methyl)-N-cycloheptylbenzamide
-
Mus musculus

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
adipose tissue
-
Mus musculus
-
adipose tissue
-
Homo sapiens
-
liver
-
Mus musculus
-
liver
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cortisone + NADPH + H+
-
Mus musculus cortisol + NADP+
-
?
cortisone + NADPH + H+
-
Homo sapiens cortisol + NADP+
-
?

Synonyms

Synonyms Comment Organism
11beta-hydroxysteroid dehydrogenase type 1
-
Mus musculus
11beta-hydroxysteroid dehydrogenase type 1
-
Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000002
-
pH not specified in the publication, temperature not specified in the publication Mus musculus 4-([[(3-chlorophenyl)sulfonyl]amino]methyl)-N-cycloheptyl-N-methylbenzamide
0.000002
-
pH not specified in the publication, temperature not specified in the publication Mus musculus 4-([[(3-chlorophenyl)sulfonyl]amino]methyl)-N-cycloheptyl-N-propylbenzamide
0.000002
-
pH not specified in the publication, temperature not specified in the publication Homo sapiens 4-([[(3-chlorophenyl)sulfonyl]amino]methyl)-N-cycloheptyl-N-propylbenzamide
0.000002
-
pH not specified in the publication, temperature not specified in the publication Mus musculus N-butyl-4-([[(3-chlorophenyl)sulfonyl]amino]methyl)-N-cycloheptylbenzamide
0.000008
-
pH not specified in the publication, temperature not specified in the publication Mus musculus glycyrrhizic acid
0.00001
-
pH not specified in the publication, temperature not specified in the publication Homo sapiens glycyrrhizic acid
0.00001
-
pH not specified in the publication, temperature not specified in the publication Mus musculus 4-([[(3-chlorophenyl)sulfonyl]amino]methyl)-N-(tricyclo[3.3.1.13,7]dec-1-yl)benzamide
0.000014
-
pH not specified in the publication, temperature not specified in the publication Homo sapiens 4-([[(3-chlorophenyl)sulfonyl]amino]methyl)-N-(tricyclo[3.3.1.13,7]dec-1-yl)benzamide
0.000015
-
pH not specified in the publication, temperature not specified in the publication Mus musculus 4-([[(3-chlorophenyl)sulfonyl]amino]methyl)-N-cycloheptylbenzamide
0.000047
-
pH not specified in the publication, temperature not specified in the publication Homo sapiens N-butyl-4-([[(3-chlorophenyl)sulfonyl]amino]methyl)-N-cycloheptylbenzamide
0.000049
-
pH not specified in the publication, temperature not specified in the publication Homo sapiens 4-([[(3-chlorophenyl)sulfonyl]amino]methyl)-N-cycloheptylbenzamide
0.000131
-
pH not specified in the publication, temperature not specified in the publication Mus musculus 3-chloro-N-[4-(piperidin-1-ylcarbonyl)benzyl]benzenesulfonamide
0.000302
-
pH not specified in the publication, temperature not specified in the publication Mus musculus 4-([[(3-chlorophenyl)sulfonyl]amino]methyl)-N-cyclohexylbenzamide
0.000395
-
pH not specified in the publication, temperature not specified in the publication Mus musculus 4-([[(3-chlorophenyl)sulfonyl]amino]methyl)-N,N-diethylbenzamide
0.000411
-
pH not specified in the publication, temperature not specified in the publication Homo sapiens 4-([[(3-chlorophenyl)sulfonyl]amino]methyl)-N-cyclohexylbenzamide
0.00048
-
pH not specified in the publication, temperature not specified in the publication Mus musculus 3-chloro-N-[4-(pyrrolidin-1-ylcarbonyl)benzyl]benzenesulfonamide
0.000576
-
pH not specified in the publication, temperature not specified in the publication Mus musculus 3-chloro-N-(4-[[(2R,6S)-2,6-dimethylmorpholin-4-yl]carbonyl]benzyl)benzenesulfonamide
0.000638
-
pH not specified in the publication, temperature not specified in the publication Homo sapiens 4-([[(3-chlorophenyl)sulfonyl]amino]methyl)-N-cycloheptyl-N-methylbenzamide
0.000647
-
pH not specified in the publication, temperature not specified in the publication Homo sapiens 3-chloro-N-[4-(piperidin-1-ylcarbonyl)benzyl]benzenesulfonamide
0.000732
-
pH not specified in the publication, temperature not specified in the publication Mus musculus 4-([[(3-chlorophenyl)sulfonyl]amino]methyl)-N-cyclopentylbenzamide
0.001024
-
pH not specified in the publication, temperature not specified in the publication Mus musculus 3-chloro-N-(4-[[(2R,6S)-2,6-dimethylmorpholin-4-yl]carbonyl]benzyl)-4-fluorobenzenesulfonamide
0.00113
-
pH not specified in the publication, temperature not specified in the publication Homo sapiens 2-chloro-N-(4-[[(2R,6S)-2,6-dimethylmorpholin-4-yl]carbonyl]benzyl)benzenesulfonamide
0.001208
-
pH not specified in the publication, temperature not specified in the publication Homo sapiens N-(4-[[(2R,6S)-2,6-dimethylmorpholin-4-yl]carbonyl]benzyl)-3-(trifluoromethyl)benzenesulfonamide
0.001319
-
pH not specified in the publication, temperature not specified in the publication Mus musculus 3-chloro-N-[4-[(4-methylpiperazin-1-yl)carbonyl]benzyl]benzenesulfonamide
0.001404
-
pH not specified in the publication, temperature not specified in the publication Mus musculus 4-chloro-N-(4-[[(2R,6S)-2,6-dimethylmorpholin-4-yl]carbonyl]benzyl)benzenesulfonamide
0.001672
-
pH not specified in the publication, temperature not specified in the publication Homo sapiens 3-chloro-N-(4-[[(2R,6S)-2,6-dimethylmorpholin-4-yl]carbonyl]benzyl)benzenesulfonamide
0.001733
-
pH not specified in the publication, temperature not specified in the publication Homo sapiens 3-chloro-N-[4-(pyrrolidin-1-ylcarbonyl)benzyl]benzenesulfonamide
0.002106
-
pH not specified in the publication, temperature not specified in the publication Homo sapiens 4-([[(3-chlorophenyl)sulfonyl]amino]methyl)-N,N-diethylbenzamide
0.002631
-
pH not specified in the publication, temperature not specified in the publication Homo sapiens 3-chloro-N-(4-[[(2R,6S)-2,6-dimethylmorpholin-4-yl]carbonyl]benzyl)-4-fluorobenzenesulfonamide
0.002698
-
pH not specified in the publication, temperature not specified in the publication Homo sapiens 4-chloro-N-(4-[[(2R,6S)-2,6-dimethylmorpholin-4-yl]carbonyl]benzyl)benzenesulfonamide
0.003379
-
pH not specified in the publication, temperature not specified in the publication Mus musculus 3-chloro-N-[4-(morpholin-4-ylcarbonyl)benzyl]benzenesulfonamide
0.005614
-
pH not specified in the publication, temperature not specified in the publication Mus musculus N-(4-[[(2R,6S)-2,6-dimethylmorpholin-4-yl]carbonyl]benzyl)-3-(trifluoromethyl)benzenesulfonamide
0.005843
-
pH not specified in the publication, temperature not specified in the publication Mus musculus 2-chloro-N-(4-[[(2R,6S)-2,6-dimethylmorpholin-4-yl]carbonyl]benzyl)benzenesulfonamide
0.008512
-
pH not specified in the publication, temperature not specified in the publication Homo sapiens 4-([[(3-chlorophenyl)sulfonyl]amino]methyl)-N-cyclopentylbenzamide
0.01449
-
pH not specified in the publication, temperature not specified in the publication Homo sapiens 3-chloro-N-[4-(morpholin-4-ylcarbonyl)benzyl]benzenesulfonamide
0.0159
-
pH not specified in the publication, temperature not specified in the publication Homo sapiens 3-chloro-N-[4-[(4-methylpiperazin-1-yl)carbonyl]benzyl]benzenesulfonamide