Inhibitors | Comment | Organism | Structure |
---|---|---|---|
PF-877423 | specific 11beta-HSD1 inhibitor | Homo sapiens | |
PF-877423 | specific 11beta-HSD1 inhibitor | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
pancreatic islet | 11beta-HSD1 co-localises with glucagon in the periphery of pancreatic islets, but not with insulin or somatostatin | Mus musculus | - |
pancreatic islet | 11beta-HSD1 co-localises with glucagon in the periphery of pancreatic islets, but not with insulin or somatostatin | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
11-dehydrocorticosterone + NADPH | - |
Mus musculus | corticosterone + NADP+ | - |
? | |
11-dehydrocorticosterone + NADPH | - |
Homo sapiens | corticosterone + NADP+ | - |
? | |
cortisone + NADPH + H+ | - |
Mus musculus | cortisol + NADP+ | - |
? | |
cortisone + NADPH + H+ | - |
Homo sapiens | cortisol + NADP+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
11beta-HSD1 | - |
Mus musculus |
11beta-HSD1 | - |
Homo sapiens |
11beta-hydroxysteroid dehydrogenase type 1 | - |
Mus musculus |
11beta-hydroxysteroid dehydrogenase type 1 | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Mus musculus | |
NADPH | - |
Homo sapiens |