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Literature summary for 1.1.1.146 extracted from
- Prostaglandin F2alpha stimulates 11beta-hydroxysteroid dehydrogenase 1 enzyme bioactivity and protein expression in bovine endometrial stromal cells (2009), Biol. Reprod., 80, 657-664.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | the conversion rate of cortisone to cortisol is significantly stimulated by 0.001 and 0.01 mM prostaglandin F2alpha, but not by prostaglandin E2. Although prostaglandin F2alpha (0.001 mM) does not affect the expression of HSD11B in cultured stromal cells, it significantly stimulates the protein expression of HSD11B. Cycloheximide abolishes the stimulatory effect of prostaglandin F2alpha on HSD11B protein expression in endometrial stromal cells, indicating that prostaglandin F2alpha increases HSD11B1 protein expression by stimulating a posttranscriptional process rather than a transcriptional mechanism. | Bos taurus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| indomethacin | significant inhibition at 0.01 mM, the inhibitory effect of indomethacin on HSD11B bioactivity is abolished by 0.001 mM prostaglandin F2alpha, but not by prostaglandin E2 | Bos taurus |  |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 32000 | - |
SDS-PAGE | Bos taurus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| endometrial stromal cell | - |
Bos taurus | - |
| uterine endometrium | - |
Bos taurus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| cortisol + NADP+ | - |
Bos taurus | cortisone + NADPH | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 11beta-hydroxysteroid dehydrogenase 1 | - |
Bos taurus |
| HSD11B | - |
Bos taurus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADP+ | - |
Bos taurus | |
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Release 2023.1 (January 2023)
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