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Literature summary for 1.1.1.146 extracted from
- Mono-(2-ethylhexyl) phthalate (MEHP) regulates glucocorticoid metabolism through 11beta-hydroxysteroid dehydrogenase 2 in murine gonadotrope cells (2009), Biochem. Biophys. Res. Commun., 389, 305-309.
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 34000 | - |
11beta-HSD1, SDS-PAGE | Mus musculus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| corticosterone + NADP+ | Mus musculus | - |
11-dehydrocorticosterone + NADPH | - |
ir |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| kidney | - |
Mus musculus | - |
| liver | - |
Mus musculus | - |
| additional information | 11beta-HSD2, but not 11beta-HSD1, is strongly expressed in LbetaT2 cells | Mus musculus | - |
| additional information | LbetaT2 cell of 11beta-HSD2, but not 11beta-HSD1, is strongly expressed in LbetaT2 cells | Mus musculus | - |
| testis | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| corticosterone + NADP+ | - |
Mus musculus | 11-dehydrocorticosterone + NADPH | - |
ir | |
| corticosterone + NADP+ | 11beta-HSD1 | Mus musculus | 11-dehydrocorticosterone + NADPH | - |
r | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 11-beta-HSD1 (oxidase) NADP+ | - |
Mus musculus |
| 11beta-HSD1 | - |
Mus musculus |
| 11beta-hydroxysteroid dehydrogenase 1 | - |
Mus musculus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADP+ | preferred cofactor of 11beta-HSD1 | Mus musculus | |
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Release 2023.1 (January 2023)
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