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Literature summary for 1.1.1.146 extracted from

  • Hennebert, O.; Le Mee, S.; Pernelle, C.; Morfin, R.
    5Alpha-androstane-3beta,7alpha,17beta-triol and 5alpha-androstane-3beta,7beta,17beta-triol as substrates for the human 11beta-hydroxysteroid dehydrogenase type 1 (2007), Steroids, 72, 855-864.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression in Saccharomyces cerevisiae Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
7-oxo-5alpha-androstane-3beta,17beta-diol mixed type inhibition of cortisone reduction Homo sapiens
7-oxo-dehydroepiandrosterone mixed type inhibition of cortisone reduction Homo sapiens
7-oxo-epiandrosterone competitive type inhibition of cortisone reduction Homo sapiens
7alpha-hydroxy-dehydroepiandrosterone competitive type inhibition of cortisol oxidation Homo sapiens
7alpha-hydroxy-epiandrosterone competitive type inhibition of cortisol oxidation Homo sapiens
7beta-hydroxy-dehydroepiandrosterone competitive type inhibition of cortisol oxidation Homo sapiens
7beta-hydroxy-epiandrosterone mixed type inhibition of cortisol oxidation Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0012
-
5alpha-androstane-3beta,7alpha,17beta-triol pH 7.4, 28°C Homo sapiens
0.0044
-
cortisone pH 7.4, 28°C Homo sapiens
0.0051
-
7-oxo-5alpha-androstane-3beta,17beta-diol product 5alpha-androstane-3beta,7alpha,17beta-triol, pH 7.4, 28°C Homo sapiens
0.0065
-
cortisol pH 7.4, 28°C Homo sapiens
0.0068
-
7-oxo-5alpha-androstane-3beta,17beta-diol product 5alpha-androstane-3beta,7beta,17beta-triol, pH 7.4, 28°C Homo sapiens
0.021
-
5alpha-androstane-3beta,7beta,17beta-triol pH 7.4, 28°C Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5alpha-androstane-3beta,7alpha,17beta-triol + NADP+ interconversion of 7alpha to 7beta isoform, ratio Vmax/Km is 2 pmol min-1 microgramm-1/microMol Homo sapiens 5alpha-androstane-3beta,7beta,17beta-triol + NADPH
-
r
5alpha-androstane-3beta,7beta,17beta-triol + NADP+ interconversion of 7beta to 7alpha isoform, ratio Vmax/Km is 0.5 pmol min-1 microgramm-1/microMol Homo sapiens 5alpha-androstane-3beta,7alpha,17beta-triol + NADP
-
r
7-oxo-5alpha-androstane-3beta,17beta-diol + NADPH
-
Homo sapiens 5alpha-androstane-3beta,7alpha,17beta-triol + 5alpha-androstane-3beta,7alpha,17beta-triol + NADP+
-
r
cortisol + NADP+
-
Homo sapiens cortisone + NADPH
-
r

Cofactor

Cofactor Comment Organism Structure
NADP+
-
Homo sapiens
NADPH
-
Homo sapiens