Cloned (Comment) | Organism |
---|---|
expression in Saccharomyces cerevisiae | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
7-oxo-5alpha-androstane-3beta,17beta-diol | mixed type inhibition of cortisone reduction | Homo sapiens | |
7-oxo-dehydroepiandrosterone | mixed type inhibition of cortisone reduction | Homo sapiens | |
7-oxo-epiandrosterone | competitive type inhibition of cortisone reduction | Homo sapiens | |
7alpha-hydroxy-dehydroepiandrosterone | competitive type inhibition of cortisol oxidation | Homo sapiens | |
7alpha-hydroxy-epiandrosterone | competitive type inhibition of cortisol oxidation | Homo sapiens | |
7beta-hydroxy-dehydroepiandrosterone | competitive type inhibition of cortisol oxidation | Homo sapiens | |
7beta-hydroxy-epiandrosterone | mixed type inhibition of cortisol oxidation | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0012 | - |
5alpha-androstane-3beta,7alpha,17beta-triol | pH 7.4, 28°C | Homo sapiens | |
0.0044 | - |
cortisone | pH 7.4, 28°C | Homo sapiens | |
0.0051 | - |
7-oxo-5alpha-androstane-3beta,17beta-diol | product 5alpha-androstane-3beta,7alpha,17beta-triol, pH 7.4, 28°C | Homo sapiens | |
0.0065 | - |
cortisol | pH 7.4, 28°C | Homo sapiens | |
0.0068 | - |
7-oxo-5alpha-androstane-3beta,17beta-diol | product 5alpha-androstane-3beta,7beta,17beta-triol, pH 7.4, 28°C | Homo sapiens | |
0.021 | - |
5alpha-androstane-3beta,7beta,17beta-triol | pH 7.4, 28°C | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
5alpha-androstane-3beta,7alpha,17beta-triol + NADP+ | interconversion of 7alpha to 7beta isoform, ratio Vmax/Km is 2 pmol min-1 microgramm-1/microMol | Homo sapiens | 5alpha-androstane-3beta,7beta,17beta-triol + NADPH | - |
r | |
5alpha-androstane-3beta,7beta,17beta-triol + NADP+ | interconversion of 7beta to 7alpha isoform, ratio Vmax/Km is 0.5 pmol min-1 microgramm-1/microMol | Homo sapiens | 5alpha-androstane-3beta,7alpha,17beta-triol + NADP | - |
r | |
7-oxo-5alpha-androstane-3beta,17beta-diol + NADPH | - |
Homo sapiens | 5alpha-androstane-3beta,7alpha,17beta-triol + 5alpha-androstane-3beta,7alpha,17beta-triol + NADP+ | - |
r | |
cortisol + NADP+ | - |
Homo sapiens | cortisone + NADPH | - |
r |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADP+ | - |
Homo sapiens | |
NADPH | - |
Homo sapiens |