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Literature summary for 1.1.1.146 extracted from

  • Arai, N.; Masuzaki, H.; Tanaka, T.; Ishii, T.; Yasue, S.; Kobayashi, N.; Tomita, T.; Noguchi, M.; Kusakabe, T.; Fujikura, J.; Ebihara, K.; Hirata, M.; Hosoda, K.; Hayashi, T.; Sawai, H.; Minokoshi, Y.; Nakao, K.
    Ceramide and adenosine 5-monophosphate-activated protein kinase are two novel regulators of 11beta-hydroxysteroid dehydrogenase type 1 expression and activity in cultured preadipocytes (2007), Endocrinology, 148, 5268-5277.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
5-aminoimidazole-4-carboxamide ribonucleoside treatment augments the induction of enzyme expression and activity by C2 ceramide Mus musculus
bacterial sphingomyelinase
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Mus musculus
C2 ceramide treatment of 3T3-L1 preadipocytes robustly induces the expression of isoform 11beta-HSD1 via induction of CCAAT/enhancer-binding protein beta and its binding to the 11beta-HSD1 promoter Mus musculus
sphingosine 1-phosphate
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Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
3T3-L1 cell
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Mus musculus
-