Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(11beta)-11-hydroxyallopregnanolone | - |
Homo sapiens | |
(11beta)-11-hydroxyprogesterone | - |
Homo sapiens | |
(3alpha,5alpha)-3,11,21-trihydroxypregn-11-en-20-one | - |
Homo sapiens | |
11-dehydrocortisterone | - |
Ovis aries | |
11-oxo-3alpha,5alpha-tetrahydrotestosterone | - |
Homo sapiens | |
11-oxo-3beta,5alpha-tetrathydrotestosterone | - |
Ovis aries | |
11-oxo-allopregnanolone | - |
Homo sapiens | |
11-oxo-allopregnanolone | - |
Ovis aries | |
11-oxo-androstenedione | - |
Homo sapiens | |
11-oxo-progesterone | - |
Homo sapiens | |
11-oxo-progesterone | - |
Ovis aries | |
11-oxo-testosterone | - |
Homo sapiens | |
11-oxo-testosterone | - |
Ovis aries | |
11beta-hydroxy-allopregnanolone | - |
Ovis aries | |
11beta-hydroxy-androstanediol | - |
Homo sapiens | |
11beta-hydroxy-testosterone | - |
Homo sapiens | |
11beta-hydroxyandrostanediol | - |
Ovis aries | |
11beta-hydroxyandrostenedione | - |
Ovis aries | |
11beta-hydroxyprogesterone | - |
Ovis aries | |
11beta-hydroxytestosterone | - |
Ovis aries | |
3alpha,5alpha-tetrahydro-dehydrocortisterone | - |
Ovis aries | |
3alpha,5alpha-tetrahydroaldosterone | - |
Ovis aries | |
3alpha,5alpha-tetrahydrocorticosterone | - |
Homo sapiens | |
3alpha,5alpha-tetrahydrocorticosterone | - |
Ovis aries | |
3alpha,5alpha-tetrahydrocortisol | - |
Ovis aries | |
5alpha-dihydrocorticosterone | - |
Homo sapiens | |
5alpha-dihydrocorticosterone | - |
Ovis aries | |
additional information | steroid hormones, adrenocorticosteroid derivatives, progesteron and androgen steroid hormones, with 5alpha-ring A reduced-configuration selectively inhibit isozyme 11beta-HSD2, while 5beta-derivatives are inactive | Ovis aries |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
1,2-dehydrocortisol + NADP+ | Homo sapiens | - |
1,2-dehydrocortisone + NADPH | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Ovis aries | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
adrenal gland | - |
Ovis aries | - |
kidney | - |
Ovis aries | - |
Leydig cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
1,2-dehydrocortisol + NADP+ | - |
Homo sapiens | 1,2-dehydrocortisone + NADPH | - |
r |
Synonyms | Comment | Organism |
---|---|---|
11beta-HSD1 | - |
Homo sapiens |
11beta-HSD1 | - |
Ovis aries |
11beta-hydroxysteroid dehydrogenase isoforms 1 | - |
Homo sapiens |
11beta-hydroxysteroid dehydrogenase isoforms 1 | - |
Ovis aries |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
37 | - |
assay at | Ovis aries |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8.4 | - |
assay at | Homo sapiens |
8.4 | - |
assay at | Ovis aries |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00005 | - |
pH 8.4, 37°C | Ovis aries | 11beta-hydroxyprogesterone | |
0.00012 | - |
pH 8.4, 37°C | Ovis aries | 11beta-hydroxy-allopregnanolone | |
0.00015 | - |
pH 8.4, 37°C | Ovis aries | 5alpha-dihydrocorticosterone | |
0.00026 | - |
pH 8.4, 37°C | Ovis aries | 3alpha,5alpha-tetrahydrocorticosterone | |
0.00035 | - |
pH 8.4, 37°C | Ovis aries | 11beta-hydroxytestosterone | |
0.0004 | - |
pH 8.4, 37°C | Ovis aries | 11-oxo-progesterone | |
0.00047 | - |
pH 8.4, 37°C | Ovis aries | 11-dehydrocortisterone | |
0.0005 | - |
pH 8.4, 37°C | Ovis aries | 3alpha,5alpha-tetrahydroaldosterone | |
0.00065 | - |
reductase reaction, pH 8.4, 37°C | Homo sapiens | 11-oxo-3alpha,5alpha-tetrahydrotestosterone | |
0.0007 | - |
reductase reaction, pH 8.4, 37°C | Homo sapiens | (3alpha,5alpha)-3,11,21-trihydroxypregn-11-en-20-one | |
0.0008 | - |
pH 8.4, 37°C | Ovis aries | 3alpha,5alpha-tetrahydro-dehydrocortisterone | |
0.0008 | - |
reductase reaction, pH 8.4, 37°C | Homo sapiens | 11-oxo-allopregnanolone | |
0.0013 | - |
dehydrogenase reaction, pH 8.4, 37°C | Homo sapiens | 3alpha,5alpha-tetrahydrocorticosterone | |
0.00135 | - |
pH 8.4, 37°C | Ovis aries | 11-oxo-testosterone | |
0.0015 | - |
pH 8.4, 37°C | Ovis aries | 11-oxo-allopregnanolone | |
0.0021 | - |
dehydrogenase reaction, pH 8.4, 37°C | Homo sapiens | 5alpha-dihydrocorticosterone | |
0.003 | - |
dehydrogenase reaction, pH 8.4, 37°C | Homo sapiens | (11beta)-11-hydroxyallopregnanolone | |
0.0045 | - |
pH 8.4, 37°C | Ovis aries | 11beta-hydroxyandrostanediol | |
0.005 | - |
dehydrogenase reaction, dehydrogenase reaction, pH 8.4, 37°C | Homo sapiens | 11beta-hydroxy-androstanediol | |
0.0056 | - |
dehydrogenase reaction, pH 8.4, 37°C | Homo sapiens | (11beta)-11-hydroxyprogesterone | |
0.0063 | - |
reductase reaction, pH 8.4, 37°C | Homo sapiens | 5alpha-dihydrocorticosterone | |
0.0078 | - |
pH 8.4, 37°C | Ovis aries | 11beta-hydroxyandrostenedione | |
0.008 | - |
pH 8.4, 37°C | Ovis aries | 3alpha,5alpha-tetrahydrocortisol | |
0.008 | - |
pH 8.4, 37°C | Ovis aries | 11-oxo-3beta,5alpha-tetrathydrotestosterone | |
0.008 | - |
dehydrogenase reaction, pH 8.4, 37°C | Homo sapiens | (3alpha,5alpha)-3,11,21-trihydroxypregn-11-en-20-one | |
0.009 | - |
dehydrogenase reaction, pH 8.4, 37°C | Homo sapiens | 11beta-hydroxy-testosterone | |
0.0095 | - |
pH 8.4, 37°C | Homo sapiens | 11-oxo-progesterone | |
0.0115 | - |
reductase reaction, pH 8.4, 37°C | Homo sapiens | 11beta-hydroxy-androstanediol | |
0.018 | - |
reductase reaction, pH 8.4, 37°C | Homo sapiens | 11-oxo-testosterone | |
0.021 | - |
reductase reaction, pH 8.4, 37°C | Homo sapiens | 11-oxo-androstenedione | |
0.05 | - |
dehydrogenase reaction, pH 8.4, 37°C | Homo sapiens | 11-oxo-3alpha,5alpha-tetrahydrotestosterone | |
0.05 | - |
reductase reaction, pH 8.4, 37°C | Homo sapiens | 3alpha,5alpha-tetrahydrocorticosterone |