Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | isozyme 11beta-HSD1 is induced by cortisol, mechanism through induction of promoter activity, overview | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | - |
Homo sapiens | 16020 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
cortisone + NADPH + H+ | Homo sapiens | isozyme 11beta-HSD1 catalyzes the forward reaction with cofactor NADPH | cortisol + NADP+ | - |
ir |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
isozyme 11beta-HSD1 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
chorion | chorionic trophoblast cell | Homo sapiens | - |
trophoblast | chorionic trophoblast cell | Homo sapiens | - |
uterus | expression of isozyme 11beta-HSD1 in intrauterine tissue, overview | Homo sapiens | - |
WISH cell | amnion-derived cell line | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
cortisone + NADPH + H+ | isozyme 11beta-HSD1 catalyzes the forward reaction with cofactor NADPH | Homo sapiens | cortisol + NADP+ | - |
ir |
Synonyms | Comment | Organism |
---|---|---|
11beta-HSD1 | - |
Homo sapiens |
11beta-hydroxysteroid dehydrogenase type 1 | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | 11beta-HSD1 | Homo sapiens |