Inhibitors | Comment | Organism | Structure |
---|---|---|---|
carbenoxolone | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Homo sapiens | - |
- |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
40000 | - |
1 * 40000, isozyme HSD1, SDS-PAGE | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
cortisol + NADP+ | Homo sapiens | inactivation of the biologically active glucocorticoid | cortisone + NADPH | - |
r | |
additional information | Homo sapiens | enzyme inhibition affects the glucocorticoid- and dexamethasone-mediated regulation of surfactant protein A metabolism, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
isozymes HSD1 and HSD2 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
lung | adult and fetal, isozymes HSD1 and HSD2 | Homo sapiens | - |
NCI-H441 cell | lung epithelial cell line, isozymes HSD1 and HSD2 | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
cortisol + NADP+ | - |
Homo sapiens | cortisone + NADPH | - |
r | |
cortisol + NADP+ | inactivation of the biologically active glucocorticoid | Homo sapiens | cortisone + NADPH | - |
r | |
additional information | enzyme inhibition affects the glucocorticoid- and dexamethasone-mediated regulation of surfactant protein A metabolism, overview | Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
monomer | 1 * 40000, isozyme HSD1, SDS-PAGE | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
11beta-hydroxysteroid dehydrogenase type 1 | - |
Homo sapiens |
HSD1 | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADP+ | - |
Homo sapiens | |
NADPH | - |
Homo sapiens |