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Literature summary for 1.1.1.146 extracted from

  • Monder, C.; Lakshmi, V.
    Corticosteroid 11beta-hydroxysteroid dehydrogenase activities in vertebrate liver (1988), Steroids, 52, 515-528.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
Triton DF-18
-
Rattus sp.
Triton DF-18 microsome-linked property to detergent-dependent release of activity for all mammalian, but not for rat enzyme Mammalia

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
11beta,21-dihydroxypregn-4-en-3,20-dione + NADP+ Mammalia
-
21-hydroxy-pregn-4-en-3,11,20-trione + NADPH + H+
-
?
11beta,21-dihydroxypregn-4-en-3,20-dione + NADP+ aves
-
21-hydroxy-pregn-4-en-3,11,20-trione + NADPH + H+
-
?
11beta,21-dihydroxypregn-4-en-3,20-dione + NADP+ dogfish
-
21-hydroxy-pregn-4-en-3,11,20-trione + NADPH + H+
-
?
11beta,21-dihydroxypregn-4-en-3,20-dione + NADP+ Rattus sp.
-
21-hydroxy-pregn-4-en-3,11,20-trione + NADPH + H+
-
?

Organism

Organism UniProt Comment Textmining
aves
-
-
-
dogfish
-
-
-
Mammalia
-
-
-
no activity in frog
-
no activity for the oxidative direction in frog, toad, mud, puppy, shark and bird livers
-
no activity in Necturus maculosus
-
-
-
no activity in shark
-
-
-
no activity in toad
-
no activity for the oxidative direction in frog, toad, mud, puppy, shark and bird livers
-
Rattus sp.
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Mammalia
-
liver
-
aves
-
liver
-
dogfish
-
liver
-
Rattus sp.
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
11beta,21-dihydroxypregn-4-en-3,20-dione + NADP+
-
Mammalia 21-hydroxy-pregn-4-en-3,11,20-trione + NADPH + H+
-
?
11beta,21-dihydroxypregn-4-en-3,20-dione + NADP+
-
aves 21-hydroxy-pregn-4-en-3,11,20-trione + NADPH + H+
-
?
11beta,21-dihydroxypregn-4-en-3,20-dione + NADP+
-
dogfish 21-hydroxy-pregn-4-en-3,11,20-trione + NADPH + H+
-
?
11beta,21-dihydroxypregn-4-en-3,20-dione + NADP+
-
Rattus sp. 21-hydroxy-pregn-4-en-3,11,20-trione + NADPH + H+
-
?