Inhibitors | Comment | Organism | Structure |
---|---|---|---|
glycyrrhizic acid | dose-dependent competitive inhibition, IC50: 1.994 mM | Cavia porcellus | |
gossypol acetic acid | dose-dependent competitive inhibition, IC50: 0.297 mM, (+)-isomer more potent inhibitor than (-)-isomer, mutant hairless strain more sensitive to inhibition than haired strain due to pharmacogenetic differences between the strains | Cavia porcellus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0027 | - |
11beta,21-dihydroxypregn-4-en-3,20-dione | - |
Cavia porcellus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
11beta,21-dihydroxypregn-4-en-3,20-dione + NADP+ | Cavia porcellus | - |
21-hydroxy-pregn-4-en-3,11,20-trione + NADPH + H+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Cavia porcellus | - |
guinea pig | - |
Cavia porcellus | - |
haired and hairless strains | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
kidney | cortex | Cavia porcellus | - |
Storage Stability | Organism |
---|---|
-70°C, 0.01 M sodium phosphate, pH 7.0, 0.25 M sucrose, 6 weeks | Cavia porcellus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
11beta,21-dihydroxypregn-4-en-3,20-dione + NADP+ | - |
Cavia porcellus | 21-hydroxy-pregn-4-en-3,11,20-trione + NADPH + H+ | - |
? |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADP+ | - |
Cavia porcellus | |
NADPH | - |
Cavia porcellus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.297 | - |
dose-dependent competitive inhibition, IC50: 0.297 mM, (+)-isomer more potent inhibitor than (-)-isomer, mutant hairless strain more sensitive to inhibition than haired strain due to pharmacogenetic differences between the strains | Cavia porcellus | gossypol acetic acid | |
1.994 | - |
dose-dependent competitive inhibition, IC50: 1.994 mM | Cavia porcellus | glycyrrhizic acid |