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Literature summary for 1.1.1.146 extracted from

  • Hult, M.; Nobel, C.S.I.; Abrahmsen, L.; Nicoll-Griffith, D.A.; Jörnvall, H.; Oppermann, U.C.T.
    Novel enzymological profiles of human 11beta-hydroxysteroid dehydrogenase type 1 (2001), Chem. Biol. Interact., 130-132, 805-8014.
    View publication on PubMed
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Cloned(Commentary)

Cloned (Comment) Organism
expression in Pichia pastoris Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0038
-
 17,21-dihydroxy-pregn-4-ene-3,11,20-trione i.e. cortisone Homo sapiens
0.0038
-
 17,21-dihydroxy-pregn-4-ene-3,11,20-trione microsomal fraction from transformed Pichia pastoris strain with human enzyme Homo sapiens
0.0092
-
 11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione i.e. cortisol Homo sapiens
0.0092
-
 11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione microsomal fraction from transformed Pichia pastoris strain with human enzyme Homo sapiens
0.0102
-
 11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione i.e. cortisol Homo sapiens
0.0102
-
 11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione purified recombinant enzyme Homo sapiens
0.02
-
 2,3-benzoylphenyl-propanoic acid microsomal fraction from transformed Pichia pastoris strain with human enzyme Homo sapiens
0.37
-
 metapyrone microsomal fraction from transformed Pichia pastoris strain with human enzyme Homo sapiens
0.581
-
 5,5-dimethyl-3-(3-fluorphenyl)-4-(4-methylsulphonyl)phenyl-2-(5H-furanone)-lactol microsomal fraction from transformed Pichia pastoris strain with human enzyme Homo sapiens
0.961
-
 5,5-dimethyl-3-(3-fluorphenyl)-4-(4-methylsulphonyl)phenyl-2-(5H-furanone)-lactol purified recombinant enzyme Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
17,21-dihydroxy-pregn-4-ene-3,11,20-trione + NADPH Homo sapiens i.e. cortisone 11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione + NADP+ i.e. cortisol r

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 isoenzyme type 1
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein
-
 Homo sapiens

Purification (Commentary)

Purification (Comment) Organism
near homogeneity, recombinant enzyme Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
17,21-dihydroxy-pregn-4-ene-3,11,20-trione + NADPH i.e. cortisone Homo sapiens 11beta,17,21-trihydroxy-pregn-4-ene-3,20-dione + NADP+ i.e. cortisol r
2,3-benzoylphenyl-propanoic acid + NADPH widely used in human and veterinarian medicine Homo sapiens 2,3-benzoylphenyl-propanol + NADP+
-
 r
2,3-benzoylphenyl-propanoic acid + NADPH i.e. ketoprofen Homo sapiens 2,3-benzoylphenyl-propanol + NADP+
-
 r
5,5-dimethyl-3-(3-fluorphenyl)-4-(4-methylsulfonyl)phenyl-2-(5H-furanone)-lactol + NADP+ i.e. DFU-lactol Homo sapiens 5,5-dimethyl-3-(3-fluorphenyl)-4-(4-methylsulfonyl)phenyl-2-(5H-furanone)-lactone + NADPH
-
 r
5,5-dimethyl-3-(3-fluorphenyl)-4-(4-methylsulfonyl)phenyl-2-(5H-furanone)-lactol + NADP+ reduced product of the selective cyclooxygenase type 2 inhibitor DFU Homo sapiens 5,5-dimethyl-3-(3-fluorphenyl)-4-(4-methylsulfonyl)phenyl-2-(5H-furanone)-lactone + NADPH
-
 r
dexamethasone + NADP+
-
 Homo sapiens 11-dehydromethasone + NADPH
-
 ?
metapyrone + NADPH + H+
-
 Homo sapiens 7alpha-hydroxycholesterol + NADP+
-
 r
metyrapone + NADPH
-
 Homo sapiens ? + NADP+
-
 r

Synonyms

Synonyms Comment Organism
11beta-HSD
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADP+
-
 Homo sapiens
NADPH
-
 Homo sapiens