Inhibitors | Comment | Organism | Structure |
---|---|---|---|
+/-gossypol | potent, competitive | Homo sapiens | |
6-hydroxyflavone | very potent, competitive | Homo sapiens | |
Biochanin A | very potent | Homo sapiens | |
bisphenol A | potent, competitive | Homo sapiens | |
daidzein | very potent | Homo sapiens | |
etomidate | very potent, competitive | Homo sapiens | |
formononetin | potent | Homo sapiens | |
genistein | very potent, competitive | Homo sapiens | |
ketoconazole | very potent | Homo sapiens | |
medroxyprogesterone | potent | Homo sapiens | |
methoxychlor | moderate, noncompetitive | Homo sapiens | |
myricetin | moderate | Homo sapiens | |
quercetin | potent | Homo sapiens | |
resveratrol | potent, competitive | Homo sapiens | |
tributyltin | potent, competitive | Homo sapiens | |
Triphenyltin | potent, competitive | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.047 | - |
dehydroepiandrosterone | pH and temperature not specified in the publication | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Homo sapiens | 5739 | - |
smooth endoplasmic reticulum | membrane-bound | Homo sapiens | 5790 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P26439 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
testis | isoenzyme HSD3B2 | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
dehydroepiandrosterone + NAD+ | - |
Homo sapiens | androst-5-en-3,17-dione + NADH + H+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
3beta-hydroxysteroid dehydrogenase | - |
Homo sapiens |
HSD3B2 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
metabolism | the enzyme is responsible for intermediate steroidogenic reaction for the synthesis of androgens, estrogens, progestins, glucocorticoids, and mineralocorticoids in the adrenal cortex, gonads, placenta, and a variety of peripheral target tissues | Homo sapiens |