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Literature summary for 1.1.1.145 extracted from
- The human 3beta-hydroxysteroid dehydrogenase/DELTA5-DELTA4 isomerase type 2 promoter is a novel target for the immediate early orphan nuclear receptor Nur77 in steroidogenic cells (2005), Endocrinology, 146, 861-869.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in MA-10 cells | Homo sapiens |
| gene HSD3B2, analysis of expression and its regulation involving Nur77 factors in H295R and MA-10 cell lines, overview | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| DELTA5-3beta-hydroxysteroid + NAD+ | Homo sapiens | the enzyme is essential for biosynthesis of all classes of steroid hormones, molecular mechanisms of enzyme regulation involving the Nur77 family of immediate-early orphan nuclear receptors, e.g. Nur77 targets the promoter of gene HSD3B2 in testicular Leygig cells, overview | DELTA4-3-oxosteroid + NADH + H+ | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
type 2 isozyme, gene HSD3B2 | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| adrenal gland | - |
Homo sapiens | - |
| gonad | - |
Homo sapiens | - |
| H295R cell | adrenal cell line | Homo sapiens | - |
| Leydig cell | - |
Homo sapiens | - |
| testis | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| DELTA5-3beta-hydroxysteroid + NAD+ | the enzyme is essential for biosynthesis of all classes of steroid hormones, molecular mechanisms of enzyme regulation involving the Nur77 family of immediate-early orphan nuclear receptors, e.g. Nur77 targets the promoter of gene HSD3B2 in testicular Leygig cells, overview | Homo sapiens | DELTA4-3-oxosteroid + NADH + H+ | - |
? | |
| DELTA5-3beta-hydroxysteroid + NAD+ | the enzyme performs the 3beta-hydroxysteroid dehydrogenase and DELTA5-DELTA4 isomerase reactions | Homo sapiens | DELTA4-3-oxosteroid + NADH + H+ | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 3beta-HSD2 | - |
Homo sapiens |
| 3beta-hydroxysteroid dehydrogenase/DELTA5-DELAT4 isomerase type 2 | - |
Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NAD+ | - |
Homo sapiens | |
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Release 2023.1 (January 2023)
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