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Literature summary for 1.1.1.145 extracted from

  • McVey, M.J.; Cooke, G.M.
    Inhibition of rat testis microsomal 3b-hydroxysteroid dehydrogenase activity by tributyltin (2003), J. Steroid Biochem. Mol. Biol., 86, 99-105.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
monooctyltin 0.081 mM, 50% inhibition; inhibition mechanism, overview Rattus norvegicus
tributyltin 0.012 mM, almost complete loss of activity; complete inhibition at 0.012 mM, the inhibition mechanism is not entirely competitive, overview Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.00042
-
dehydroepiandrosterone pH 7.5, 37°C Rattus norvegicus
0.00059
-
dehydroepiandrosterone 37°C, pH 8.4 Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Rattus norvegicus
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
dehydroepiandrosterone + NADH + H+ Rattus norvegicus
-
androsterone + NAD+
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
testis
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dehydroepiandrosterone + NAD+
-
Rattus norvegicus ?
-
r
dehydroepiandrosterone + NADH + H+
-
Rattus norvegicus androsterone + NAD+
-
?

Synonyms

Synonyms Comment Organism
3beta-HSD
-
Rattus norvegicus
3beta-hydroxysteroid dehydrogenase
-
Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
assay at Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Rattus norvegicus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
additional information
-
additional information inhibition kinetics Rattus norvegicus
0.0027
-
tributyltin pH 7.5, 37°C Rattus norvegicus
0.0027
-
tributyltin 37°C, pH 8.4 Rattus norvegicus