Cloned (Comment) | Organism |
---|---|
expression in Sf9 insect cells | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
S123A | 24% of wild-type 3beta-HSD1 activity | Homo sapiens |
S124A | no detectable 3beta-HSD1 activity | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0037 | - |
dehydroepiandrosterone | 27°C, pH 7.4 | Homo sapiens | |
0.011 | - |
dehydroepiandrosterone | 27°C, pH 7.4, S123A mutant 3betaHSD1 | Homo sapiens | |
0.034 | - |
NAD+ | 27°C, pH 7.4 | Homo sapiens | |
0.036 | - |
NAD+ | 27°C, pH 7.4, S123A mutant 3betaHSD1 | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
dehydroepiandrosterone + NAD+ | Homo sapiens | - |
androst-5-en-3,17-dione + NADH + H+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
recombinant 3beta-HSD1 | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
placenta | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
dehydroepiandrosterone + NAD+ | - |
Homo sapiens | androst-5-en-3,17-dione + NADH + H+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
3beta-hydroxysteroid dehydrogenase type 1 | - |
Homo sapiens |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.055 | - |
dehydroepiandrosterone | 27°C, pH 7.4 | Homo sapiens | |
0.06 | - |
NAD+ | 27°C, pH 7.4 | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
9.7 | - |
- |
Homo sapiens |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
7.4 | 9.7 | 37% of maximal activity at pH 7.4 | Homo sapiens |