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Literature summary for 1.1.1.145 extracted from

  • Nakajin, S.; Ishii, A.; Shinoda, M.
    Purification and characterization of 5alpha-dihydrotestosterone 3beta-hydroxysteroid dehydrogenase from mature pig testicular cytosol (1994), Biol. Pharm. Bull., 17, 1155-1160.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
AgNO3
-
Sus scrofa
Cd2+
-
Sus scrofa
Co2+
-
Sus scrofa
Cu2+
-
Sus scrofa
deoxycorticosterone
-
Sus scrofa
Disulfiram
-
Sus scrofa
Hexestrol
-
Sus scrofa
Hg2+
-
Sus scrofa
Ni2+
-
Sus scrofa
p-chloromercuribenzoate
-
Sus scrofa
Stilbestrol
-
Sus scrofa
testosterone
-
Sus scrofa

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0038
-
11beta,17alpha,21-trihydroxy-4-pregnene-3,20-dione
-
Sus scrofa
0.0152
-
prostaglandin E2
-
Sus scrofa
0.0346
-
progesterone
-
Sus scrofa
0.0461
-
11beta,17alpha,21-trihydroxy-5beta-pregnane-3,20-dione
-
Sus scrofa
0.0583
-
testosterone
-
Sus scrofa
0.0621
-
13,14-dihydro-15-keto-prostaglandin F2
-
Sus scrofa
0.0703
-
androstenedione
-
Sus scrofa
0.0827
-
11beta,17alpha,21-trihydroxy-5alpha-pregnane-3,20-dione
-
Sus scrofa
0.114
-
dehydroepiandrosterone
-
Sus scrofa
0.122
-
D-glucose
-
Sus scrofa
0.123
-
5beta-androstane-3,17-dione
-
Sus scrofa
0.13
-
13,14-dihydro-15-keto-prostaglandin F2alpha
-
Sus scrofa
0.137
-
4-Nitroacetophenone
-
Sus scrofa
0.206
-
17-hydroxyprogesterone
-
Sus scrofa
0.217
-
5alpha-pregnane-3,20-dione
-
Sus scrofa
0.231
-
17beta-hydroxy-5beta-androstane-3-one
-
Sus scrofa
0.246
-
5beta-pregnane-3,20-dione
-
Sus scrofa
0.287
-
D-galactose
-
Sus scrofa
0.319
-
4-carboxybenzaldehyde
-
Sus scrofa
0.373
-
prostaglandin E1
-
Sus scrofa
0.465
-
D-glucuronic acid
-
Sus scrofa
0.466
-
hydritantin
-
Sus scrofa
0.467
-
D-xylose
-
Sus scrofa
0.555
-
Camphorquinone
-
Sus scrofa
0.684
-
17beta-hydroxy-5alpha-androstane-3-one
-
Sus scrofa
0.69
-
caprinaldehyde
-
Sus scrofa
0.693
-
menadione
-
Sus scrofa
1.043
-
5alpha-androstane-3,17-dione
-
Sus scrofa
1.07
-
D-glyceraldehyde
-
Sus scrofa
1.663
-
cyclohexanone
-
Sus scrofa
1.966
-
4-nitrobenzaldehyde
-
Sus scrofa
2.097
-
4-benzylpyridine
-
Sus scrofa
2.366
-
Phenylglyoxal
-
Sus scrofa
2.408
-
9,10-phenanthrenequinone
-
Sus scrofa
2.651
-
methylglyoxal
-
Sus scrofa

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Sus scrofa 5829
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
28000
-
gel filtration Sus scrofa
31000
-
1 * 31000, SDS-PAGE Sus scrofa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
dehydroepiandrosterone + NAD+ Sus scrofa
-
androst-5-en-3,17-dione + NADH + H+
-
?

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Sus scrofa

Source Tissue

Source Tissue Comment Organism Textmining
testis
-
Sus scrofa
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.0041
-
-
Sus scrofa

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
11beta,17alpha,21-trihydroxy-4-pregnen-3,20-dione + NADPH
-
Sus scrofa 3beta,11beta,17alpha,21-tetrahydroxy-4-pregnen-20-one + NADP+
-
?
11beta,17alpha,21-trihydroxy-5alpha-pregnane-3,20-dione + NADPH
-
Sus scrofa 3beta,11beta,17alpha,21-tetrahydroxy-5alpha-pregnan-20-one + NADP+
-
?
11beta,17alpha,21-trihydroxy-5beta-pregnane-3,20-dione + NADPH
-
Sus scrofa 3beta,11beta,17alpha,21-tetrahydroxy-5beta-pregnan-20-one + NADP+
-
?
13,14-dihydro-15-keto-prostaglandin F2 + NADPH
-
Sus scrofa ?
-
?
13,14-dihydro-15-keto-prostaglandin F2alpha + NADPH
-
Sus scrofa ?
-
?
17-hydroxyprogesterone + NADPH
-
Sus scrofa 3beta,17-dihydroxy-4-pregnen-20-one + NADP+
-
?
17beta-hydroxy-5alpha-androstane-3-one + NADPH
-
Sus scrofa 3beta,17beta-dihydroxy-5alpha-androstane + NADP+
-
?
17beta-hydroxy-5beta-androstane-3-one + NADPH
-
Sus scrofa 3beta,17beta-dihydroxy-5beta-androstane + NADP+
-
?
4-benzylpyridine + NADPH
-
Sus scrofa ?
-
?
4-carboxybenzaldehyde + NADP+ + H2O
-
Sus scrofa 4-carboxybenzoic acid + NADPH + H+
-
?
4-nitroacetophenone + NADPH
-
Sus scrofa 1-(4-nitrophenyl)ethanol + NADP+
-
?
4-nitrobenzaldehyde + NADPH
-
Sus scrofa 4-nitrobenzyl alcohol + NADP+
-
?
5alpha-androstane-3,17-dione + NADPH
-
Sus scrofa 3beta-hydroxy-5alpha-androstane-17-one + NADP+
-
?
5alpha-dihydrotestosterone + NADPH
-
Sus scrofa 5alpha-androstane-3beta,17beta-diol + NADP+
-
?
5alpha-pregnane-3,20-dione + NAD(P)H
-
Sus scrofa 5alpha-pregnane-3beta-ol-20-one + NAD(P)+
-
?
5beta-androstane-3,17-dione + NADPH
-
Sus scrofa 3beta-hydroxy-5beta-androstane-17-one + NADP+
-
?
5beta-pregnane-3,20-dione + NAD(P)H + H+
-
Sus scrofa 5beta-pregnane-3beta-ol-20-one + NAD(P)+
-
?
9,10-phenanthrenequinone + NADPH
-
Sus scrofa ?
-
?
9,10-phenanthrenequinone + NADPH
-
Sus scrofa ? + NADP+
-
?
androstenedione + NADPH + H+
-
Sus scrofa 3beta-hydroxy-5-androsten-17-one + NADP+
-
?
camphorquinone + NADPH + H+
-
Sus scrofa camphorquinol + NADP+
-
?
caprinaldehyde + NADPH
-
Sus scrofa ?
-
?
cyclohexanone + NADPH
-
Sus scrofa cyclohexanol + NADP+
-
?
D-galactose + NADPH
-
Sus scrofa ?
-
?
D-glucose + NADPH
-
Sus scrofa ?
-
?
D-glucuronic acid + NADPH
-
Sus scrofa ?
-
?
D-glyceraldehyde + NADPH
-
Sus scrofa ?
-
?
D-xylose + NADPH
-
Sus scrofa ?
-
?
dehydroepiandrosterone + NAD+
-
Sus scrofa androst-5-en-3,17-dione + NADH + H+
-
?
dehydroepiandrosterone + NADPH
-
Sus scrofa 3beta-hydroxy-5-androsten-17-one + NADP+
-
?
hydritantin + NADPH
-
Sus scrofa ?
-
?
menadione + NADPH
-
Sus scrofa menadiol + NADP+
-
?
methylglyoxal + NADPH
-
Sus scrofa ?
-
?
phenylglyoxal + NADPH
-
Sus scrofa ?
-
?
progesterone + NADPH
-
Sus scrofa 3beta-hydroxy-4-pregnen-20-one + NADP+
-
?
prostaglandin E1 + NADPH
-
Sus scrofa ?
-
?
prostaglandin E2 + NADPH
-
Sus scrofa ?
-
?
testosterone + NADPH + H+
-
Sus scrofa 3beta,17beta-dihydroxy-4-androsten + NADP+
-
?

Subunits

Subunits Comment Organism
monomer 1 * 31000, SDS-PAGE Sus scrofa

Cofactor

Cofactor Comment Organism Structure
NADPH testicular cytosol Sus scrofa