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Literature summary for 1.1.1.141 extracted from

  • Castro-Sanchez, L.; Agra, N.; Llorente Izquierdo, C.; Motino, O.; Casado, M.; Bosca, L.; Martin-Sanz, P.
    Regulation of 15-hydroxyprostaglandin dehydrogenase expression in hepatocellular carcinoma (2013), Int. J. Biochem. Cell Biol., 45, 2501-2511.
    View publication on PubMed

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
25000
-
x * 25000, SDS-PAGE Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P15428
-
-

Source Tissue

Source Tissue Comment Organism Textmining
Chang liver cell
-
Homo sapiens
-
HEP-3B cell
-
Homo sapiens
-
Hep-G2 cell
-
Homo sapiens
-
hepatocellular carcinoma cell
-
Homo sapiens
-
HuH-6 cell
-
Homo sapiens
-
Huh-7 cell
-
Homo sapiens
-
WRL-68 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
prostaglandin E2 + NAD+
-
Homo sapiens 15-oxoprostaglandin E2 + NADH + H+
-
?

Subunits

Subunits Comment Organism
? x * 25000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
15-PGDH
-
Homo sapiens
NAD+-dependent 15-hydroxyprostaglandin dehydrogenase
-
Homo sapiens
nicotinamide adenine dinucleotide-dependent 15-hydroxyprostaglandin dehydrogenase
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Homo sapiens

Expression

Organism Comment Expression
Homo sapiens the enzyme is downregulated in human hepatoma cells with a high cyclooxygenase-2 expression down