Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.1.1.141 extracted from

  • Choi, D.; Piao, Y.L.; Wu, Y.; Cho, H.
    Control of the intracellular levels of prostaglandin E2 through inhibition of the 15-hydroxyprostaglandin dehydrogenase for wound healing (2013), Bioorg. Med. Chem., 21, 4477-4484.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL-21 LysS cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
4-((2,5-dioxopyrrolidin-3-ylidene)methyl)phenylthiophene-2-carboxylate
-
Homo sapiens
5-(2-chloro-3-(2-(pyridin-2-yl)ethoxy)benzylidene)-1,3-thiazolidine-2,4-dione
-
Homo sapiens
5-(2-chloro-4-(2-(cyclohexyloxy)ethoxy)benzylidene)-1,3-thiazolidine-2,4-dione
-
Homo sapiens
5-(2-chloro-4-(2-(propan-2-yloxy)ethoxy)benzylidene)-1,3-thiazolidine-2,4-dione
-
Homo sapiens
5-(2-chloro-4-(2-cyclohexylethoxy)benzylidene)-thiazolidine-2,4-dione
-
Homo sapiens
5-(2-chloro-4-(2-cyclopentylethoxy)benzylidene)-1,3-thiazolidine-2,4-dione
-
Homo sapiens
5-(2-chloro-4-(4-nitrobenzyloxy)benzylidene)thiazolidine-2,4-dione
-
Homo sapiens
5-(2-chloro-4-phenbutoxybenzylidene)thiazolidine-2,4-dione
-
Homo sapiens
5-(2-chloro-4-phenethoxybenzylidene)thiazolidine-2,4-dione
-
Homo sapiens
5-(2-chloro-4-phenpropoxybenzylidene)thiazolidine-2,4-dione
-
Homo sapiens
5-(3-chloro-4-((4-(prop-1-en-2-yl)cyclohexyl)methoxy)benzylidene)-1,3-thiazolidine-2,4-dione
-
Homo sapiens
5-(3-chloro-4-((5-oxo-5,6,7,8-tetrahydronaphthalen-1-yl)oxy)benzylidene)-1,3-thiazolidine-2,4-dione
-
Homo sapiens
5-(3-chloro-4-(2-(4-methyl-1,3-thiazolidin-5-yl)ethoxy)benzylidene)-1,3-thiazolidine-2,4-dione
-
Homo sapiens
5-(3-chloro-4-(2-(5-ethylpyridin-2-yl)ethoxy)benzylidene)-1,3-thiazolidine-2,4-dione
-
Homo sapiens
5-(3-chloro-4-(2-(5-nitrofuran-2-yl)ethoxy)benzylidene)-1,3-thiazolidine-2,4-dione
-
Homo sapiens
5-(3-chloro-4-(2-(cyclohexyloxy)ethoxy)benzylidene)-1,3-thiazolidine-2,4-dione
-
Homo sapiens
5-(3-chloro-4-(2-(propan-2-yloxy)ethoxy)benzylidene)-1,3-thiazolidine-2,4-dione
-
Homo sapiens
5-(3-chloro-4-(2-(pyridin-2-yl)ethoxy)benzylidene)-1,3-thiazolidine-2,4-dione
-
Homo sapiens
5-(3-chloro-4-(2-(thiophen-2-yl)ethoxy)benzylidene)thiazolidine-2,4-dione
-
Homo sapiens
5-(3-chloro-4-(2-cyclopentylethoxy)benzylidene)-1,3-thiazolidine-2,4-dione
-
Homo sapiens
5-(3-chloro-4-(2-cyclopropylpropyl)benzylidene)-1,3-thiazolidine-2,4-dione
-
Homo sapiens
5-(3-chloro-4-(2-thiomorpholine 1,1-dioxideethoxy)benzylidene)thiazolidine-2,4-dione
-
Homo sapiens
5-(3-chloro-4-(3-(2-nitroethenyl)phenoxy)benzylidene)-1,3-thiazolidine-2,4-dione
-
Homo sapiens
5-(3-chloro-4-(3-nitrophenoxy)benzylidene)-1,3-thiazolidine-2,4-dione
-
Homo sapiens
5-(3-chloro-4-(3-phenylpropoxy)benzylidene)thiazolidine-2,4-dione
-
Homo sapiens
5-(3-chloro-4-(4-nitrobenzyloxy)benzylidene)thiazolidine-2,4-dione
-
Homo sapiens
5-(3-chloro-4-(4-phenylbutoxy)benzylidene)thiazolidine-2,4-dione
-
Homo sapiens
5-(3-chloro-4-(cyclobutylmethoxy)benzylidene)-1,3-thiazolidine-2,4-dione
-
Homo sapiens
5-(3-chloro-4-(cyclopentylmethoxy)benzylidene)-1,3-thiazolidine-2,4-dione
-
Homo sapiens
5-(3-chloro-4-phenylethoxybenzylidene)thiazolidine-2,4-dione
-
Homo sapiens
5-(4-(1,3-benzodioxol-5-ylmethoxy)-3-chlorobenzylidene)-1,3-thiazolidine-2,4-dione
-
Homo sapiens
5-(4-(benzyloxy)-2-chlorobenzylidene)thiazolidine-2,4-dione
-
Homo sapiens
5-(4-(benzyloxy)-3-chlorobenzylidene)thiazolidine-2,4-dione
-
Homo sapiens
5-(4-(bicyclo[2.2.1]hept-2-ylmethoxy)-3-chlorobenzylidene)-1,3-thiazolidine-2,4-dione
-
Homo sapiens
CT-8
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
prostaglandin E2 + NAD+ Homo sapiens
-
15-oxoprostaglandin E2 + NADH + H+
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens P15428
-
-

Purification (Commentary)

Purification (Comment) Organism
glutathione Sepharose column chromatography Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
A-549 cell
-
Homo sapiens
-
HaCaT cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
prostaglandin E2 + NAD+
-
Homo sapiens 15-oxoprostaglandin E2 + NADH + H+
-
?

Synonyms

Synonyms Comment Organism
15-PGDH
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000009
-
at pH 7.5, temperature not specified in the publication Homo sapiens 5-(3-chloro-4-(cyclobutylmethoxy)benzylidene)-1,3-thiazolidine-2,4-dione
0.000011
-
at pH 7.5, temperature not specified in the publication Homo sapiens 5-(3-chloro-4-(cyclopentylmethoxy)benzylidene)-1,3-thiazolidine-2,4-dione
0.000013
-
at pH 7.5, temperature not specified in the publication Homo sapiens 5-(2-chloro-4-(2-cyclohexylethoxy)benzylidene)-thiazolidine-2,4-dione
0.00002
-
at pH 7.5, temperature not specified in the publication Homo sapiens 5-(3-chloro-4-(2-(cyclohexyloxy)ethoxy)benzylidene)-1,3-thiazolidine-2,4-dione
0.00002
-
at pH 7.5, temperature not specified in the publication Homo sapiens 5-(3-chloro-4-phenylethoxybenzylidene)thiazolidine-2,4-dione
0.000038
-
at pH 7.5, temperature not specified in the publication Homo sapiens 5-(3-chloro-4-(3-phenylpropoxy)benzylidene)thiazolidine-2,4-dione
0.000042
-
at pH 7.5, temperature not specified in the publication Homo sapiens 5-(2-chloro-4-(2-cyclopentylethoxy)benzylidene)-1,3-thiazolidine-2,4-dione
0.000048
-
at pH 7.5, temperature not specified in the publication Homo sapiens 5-(4-(benzyloxy)-3-chlorobenzylidene)thiazolidine-2,4-dione
0.000048
-
at pH 7.5, temperature not specified in the publication Homo sapiens 5-(3-chloro-4-(4-phenylbutoxy)benzylidene)thiazolidine-2,4-dione
0.000051
-
at pH 7.5, temperature not specified in the publication Homo sapiens CT-8
0.000052
-
at pH 7.5, temperature not specified in the publication Homo sapiens 5-(2-chloro-4-phenpropoxybenzylidene)thiazolidine-2,4-dione
0.000059
-
at pH 7.5, temperature not specified in the publication Homo sapiens 5-(3-chloro-4-(3-(2-nitroethenyl)phenoxy)benzylidene)-1,3-thiazolidine-2,4-dione
0.000071
-
at pH 7.5, temperature not specified in the publication Homo sapiens 5-(3-chloro-4-((5-oxo-5,6,7,8-tetrahydronaphthalen-1-yl)oxy)benzylidene)-1,3-thiazolidine-2,4-dione
0.000075
-
at pH 7.5, temperature not specified in the publication Homo sapiens 5-(3-chloro-4-((4-(prop-1-en-2-yl)cyclohexyl)methoxy)benzylidene)-1,3-thiazolidine-2,4-dione
0.000081
-
at pH 7.5, temperature not specified in the publication Homo sapiens 5-(2-chloro-4-phenbutoxybenzylidene)thiazolidine-2,4-dione
0.000084
-
at pH 7.5, temperature not specified in the publication Homo sapiens 5-(3-chloro-4-(2-(thiophen-2-yl)ethoxy)benzylidene)thiazolidine-2,4-dione
0.000099
-
at pH 7.5, temperature not specified in the publication Homo sapiens 5-(3-chloro-4-(2-cyclopentylethoxy)benzylidene)-1,3-thiazolidine-2,4-dione
0.0001
-
at pH 7.5, temperature not specified in the publication Homo sapiens 5-(3-chloro-4-(3-nitrophenoxy)benzylidene)-1,3-thiazolidine-2,4-dione
0.000123
-
at pH 7.5, temperature not specified in the publication Homo sapiens 5-(3-chloro-4-(2-(5-nitrofuran-2-yl)ethoxy)benzylidene)-1,3-thiazolidine-2,4-dione
0.000132
-
at pH 7.5, temperature not specified in the publication Homo sapiens 5-(3-chloro-4-(2-cyclopropylpropyl)benzylidene)-1,3-thiazolidine-2,4-dione
0.000165
-
at pH 7.5, temperature not specified in the publication Homo sapiens 5-(4-(bicyclo[2.2.1]hept-2-ylmethoxy)-3-chlorobenzylidene)-1,3-thiazolidine-2,4-dione
0.000178
-
at pH 7.5, temperature not specified in the publication Homo sapiens 5-(2-chloro-4-phenethoxybenzylidene)thiazolidine-2,4-dione
0.000193
-
at pH 7.5, temperature not specified in the publication Homo sapiens 5-(4-(1,3-benzodioxol-5-ylmethoxy)-3-chlorobenzylidene)-1,3-thiazolidine-2,4-dione
0.000211
-
at pH 7.5, temperature not specified in the publication Homo sapiens 5-(2-chloro-4-(2-(cyclohexyloxy)ethoxy)benzylidene)-1,3-thiazolidine-2,4-dione
0.000223
-
at pH 7.5, temperature not specified in the publication Homo sapiens 5-(3-chloro-4-(2-thiomorpholine 1,1-dioxideethoxy)benzylidene)thiazolidine-2,4-dione
0.000264
-
at pH 7.5, temperature not specified in the publication Homo sapiens 4-((2,5-dioxopyrrolidin-3-ylidene)methyl)phenylthiophene-2-carboxylate
0.000487
-
at pH 7.5, temperature not specified in the publication Homo sapiens 5-(4-(benzyloxy)-2-chlorobenzylidene)thiazolidine-2,4-dione
0.00093
-
at pH 7.5, temperature not specified in the publication Homo sapiens 5-(3-chloro-4-(4-nitrobenzyloxy)benzylidene)thiazolidine-2,4-dione
0.00105
-
at pH 7.5, temperature not specified in the publication Homo sapiens 5-(2-chloro-4-(2-(propan-2-yloxy)ethoxy)benzylidene)-1,3-thiazolidine-2,4-dione
0.002077
-
at pH 7.5, temperature not specified in the publication Homo sapiens 5-(3-chloro-4-(2-(5-ethylpyridin-2-yl)ethoxy)benzylidene)-1,3-thiazolidine-2,4-dione
0.002738
-
at pH 7.5, temperature not specified in the publication Homo sapiens 5-(3-chloro-4-(2-(propan-2-yloxy)ethoxy)benzylidene)-1,3-thiazolidine-2,4-dione
0.00444
-
at pH 7.5, temperature not specified in the publication Homo sapiens 5-(3-chloro-4-(2-(pyridin-2-yl)ethoxy)benzylidene)-1,3-thiazolidine-2,4-dione
0.00454
-
at pH 7.5, temperature not specified in the publication Homo sapiens 5-(2-chloro-4-(4-nitrobenzyloxy)benzylidene)thiazolidine-2,4-dione
0.005165
-
at pH 7.5, temperature not specified in the publication Homo sapiens 5-(3-chloro-4-(2-(4-methyl-1,3-thiazolidin-5-yl)ethoxy)benzylidene)-1,3-thiazolidine-2,4-dione
0.008915
-
at pH 7.5, temperature not specified in the publication Homo sapiens 5-(2-chloro-3-(2-(pyridin-2-yl)ethoxy)benzylidene)-1,3-thiazolidine-2,4-dione