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Literature summary for 1.1.1.141 extracted from

  • Liu, Z.; Wang, X.; Lu, Y.; Du, R.; Luo, G.; Wang, J.; Zhai, H.; Zhang, F.; Wen, Q.; Wu, K.; Fan, D.
    15-Hydroxyprostaglandin dehydrogenase is a tumor suppressor of human gastric cancer (2010), Cancer Biol. Ther., 10, 780-787.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Homo sapiens
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Source Tissue

Source Tissue Comment Organism Textmining
MKN-45 cell high expression level of 15-PGDH Homo sapiens
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SGC-7901 cell low expression level of 15-PGDH Homo sapiens
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Synonyms

Synonyms Comment Organism
15-hydroxyprostaglandin dehydrogenase
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Homo sapiens
15-PGDH
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Homo sapiens

General Information

General Information Comment Organism
malfunction MKN45 cells stably transfected with the 15-PGDH siRNA plasmid have a significantly increased proliferation rate. SGC7901 cells (disclosing a low expression level of 15-PGDH) stably transfected with the 15-PGDH cDNA have a significantly decreased growth rate. Increased expression of 15-PGDH suppresses clone formation of gastric cancer cells in plate and soft agar colony formation assays in vitro and suppressed tumor formation in athymic nude mice in vivo. Stable silencing of 15-PGDH in gastric cancer cells also enhances cell cycle entry in vitro Homo sapiens
physiological function 15-PGDH has a suppressive role and that its upregulation could partly reverse the malignant growth potential of gastric cancer cells both in vitro and in vivo Homo sapiens