Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
MKN-45 cell | high expression level of 15-PGDH | Homo sapiens | - |
SGC-7901 cell | low expression level of 15-PGDH | Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
15-hydroxyprostaglandin dehydrogenase | - |
Homo sapiens |
15-PGDH | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | MKN45 cells stably transfected with the 15-PGDH siRNA plasmid have a significantly increased proliferation rate. SGC7901 cells (disclosing a low expression level of 15-PGDH) stably transfected with the 15-PGDH cDNA have a significantly decreased growth rate. Increased expression of 15-PGDH suppresses clone formation of gastric cancer cells in plate and soft agar colony formation assays in vitro and suppressed tumor formation in athymic nude mice in vivo. Stable silencing of 15-PGDH in gastric cancer cells also enhances cell cycle entry in vitro | Homo sapiens |
physiological function | 15-PGDH has a suppressive role and that its upregulation could partly reverse the malignant growth potential of gastric cancer cells both in vitro and in vivo | Homo sapiens |