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Literature summary for 1.1.1.141 extracted from

  • Wu, Y.; Tai, H.H.; Cho, H.
    Synthesis and SAR of thiazolidinedione derivatives as 15-PGDH inhibitors (2010), Bioorg. Med. Chem., 18, 1428-1433.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
5-(4-((4-methylcyclohexyl)methoxy)benzylidene) thiazolidine-2,4-dione
-
Homo sapiens
5-(4-(2-(thiophen-2-yl)ethoxy)benzylidene)thiazolidine-2,4-dione
-
Homo sapiens
5-(4-(2-(thiophen-3-yl)ethoxy)benzylidene)thiazolidine-2,4-dione
-
Homo sapiens
5-(4-(2-cyclopentylethoxy)benzylidene)thiazolidine-2,4-dione
-
Homo sapiens
5-(4-(4-(chloromethyl)benzyloxy)benzylidene) thiazolidine-2,4-dione
-
Homo sapiens
5-(4-(cyclopentylmethoxy)benzylidene)thiazolidine-2,4-dione
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
placenta
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+
-
Homo sapiens (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+
-
?

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000031
-
pH 7.5, temperature not specified in the publication Homo sapiens 5-(4-(2-(thiophen-2-yl)ethoxy)benzylidene)thiazolidine-2,4-dione
0.000045
-
pH 7.5, temperature not specified in the publication Homo sapiens 5-(4-(cyclopentylmethoxy)benzylidene)thiazolidine-2,4-dione
0.000052
-
pH 7.5, temperature not specified in the publication Homo sapiens 5-(4-((4-methylcyclohexyl)methoxy)benzylidene) thiazolidine-2,4-dione
0.00006
-
pH 7.5, temperature not specified in the publication Homo sapiens 5-(4-(2-(thiophen-3-yl)ethoxy)benzylidene)thiazolidine-2,4-dione
0.000116
-
pH 7.5, temperature not specified in the publication Homo sapiens 5-(4-(2-cyclopentylethoxy)benzylidene)thiazolidine-2,4-dione
0.000124
-
pH 7.5, temperature not specified in the publication Homo sapiens 5-(4-(4-(chloromethyl)benzyloxy)benzylidene) thiazolidine-2,4-dione