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Literature summary for 1.1.1.141 extracted from

  • Roizen, J.D.; Asada, M.; Tong, M.; Tai, H.H.; Muglia, L.J.
    Preterm birth without progesterone withdrawal in 15-hydroxyprostaglandin dehydrogenase hypomorphic mice (2008), Mol. Endocrinol., 22, 105-112.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine 15-hydroxyprostaglandin dehydrogenase hypomorphic mice show a decreased level of enzyme mRNA and activity in all tissues examined. Mice show spontaneous preterm labor in the absence of progesterone withdrawal, and the onset of labor is preceded by prematurely increased concentrations of prostaglandin E2 and F2alpha. The fetal genotype plays a role in birth timing Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information 15-hydroxyprostaglandin dehydrogenase hypomorphic mice show a decreased level of enzyme mRNA and activity in all tissues examined. Mice show spontaneous preterm labor in the absence of progesterone withdrawal, and the onset of labor is preceded by prematurely increased concentrations of prostaglandin E2 and F2alpha. The fetal genotype plays a role in birth timing Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
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