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Literature summary for 1.1.1.141 extracted from
- Renal localization and regulation of 15-hydroxyprostaglandin dehydrogenase (2008), Am. J. Physiol. Renal Physiol., 294, F433-F439.
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
cyclooxygenase-2 knock-out mice | - |
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| adrenal cortex | both 15-hydroxyprostaglandin dehydrogenase mRNA and protein levels are significantly higher in kidney cortex than in papilla. Enzyme is mainly localized to the tubular epithelial cells in kidney cortex and outer medulla | Rattus norvegicus | - |
| kidney | - |
Rattus norvegicus | - |
| kidney | intense immunofluorescent staining for 15-hydroxyprostaglandin dehydrogenase in macula densa and glomerulus of cyclooxygenase-2 knock-out mice | Mus musculus | - |
| macula densa | intense immunofluorescent staining for 15-hydroxyprostaglandin dehydrogenase in macula densa and glomerulus of cyclooxygenase-2 knock-out mice | Mus musculus | - |
| MMDD1 cell | macula densa cell line, significantly lower enzyme levels than in a proximal tubule cell line. Treatment with an inhibitor of cyclooxygenase-2 increases enzyme level | Rattus norvegicus | - |
| renal glomerulus | intense immunofluorescent staining for 15-hydroxyprostaglandin dehydrogenase in macula densa and glomerulus of cyclooxygenase-2 knock-out mice | Mus musculus | - |
| renal papilla | - |
Rattus norvegicus | - |
| renal tubule | enzyme is mainly localized to the tubular epithelial cells in kidney cortex and outer medulla | Rattus norvegicus | - |
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Release 2023.1 (January 2023)
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