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Literature summary for 1.1.1.141 extracted from

  • Myung, S.J.; Rerko, R.M.; Yan, M.; Platzer, P.; Guda, K.; Dotson, A.; Lawrence, E.; Dannenberg, A.J.; Lovgren, A.K.; Luo, G.; Pretlow, T.P.; Newman, R.A.; Willis, J.; Dawson, D.; Markowitz, S.D.
    15-Hydroxyprostaglandin dehydrogenase is an in vivo suppressor of colon tumorigenesis (2006), Proc. Natl. Acad. Sci. USA, 103, 12098-12102.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+ Mus musculus i.e. 15-hydroxyprostaglandin or (15S)-PGE2 (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+
-
?
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+ Mus musculus C57/BL6J i.e. 15-hydroxyprostaglandin or (15S)-PGE2 (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+
-
?
additional information Mus musculus the enzyme is an in vivo suppressor of colon tumorigenesis, mechanism of conferring increased susceptibility to colon neoplasia, overview ?
-
?
additional information Mus musculus C57/BL6J the enzyme is an in vivo suppressor of colon tumorigenesis, mechanism of conferring increased susceptibility to colon neoplasia, overview ?
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
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C57BL/6J mice
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Mus musculus C57/BL6J
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C57BL/6J mice
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Source Tissue

Source Tissue Comment Organism Textmining
colon distribution of enzyme expression within the tissue in situ, overview Mus musculus
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colonic cancer cell highly reduced enzyme expression in colon cancers, distribution of enzyme expression within the tissue in situ, overview Mus musculus
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small intestine
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Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+ i.e. 15-hydroxyprostaglandin or (15S)-PGE2 Mus musculus (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+
-
?
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+ i.e. 15-hydroxyprostaglandin or (15S)-PGE2 Mus musculus C57/BL6J (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+
-
?
additional information the enzyme is an in vivo suppressor of colon tumorigenesis, mechanism of conferring increased susceptibility to colon neoplasia, overview Mus musculus ?
-
?
additional information the enzyme is an in vivo suppressor of colon tumorigenesis, mechanism of conferring increased susceptibility to colon neoplasia, overview Mus musculus C57/BL6J ?
-
?

Synonyms

Synonyms Comment Organism
15-hydroxyprostaglandin dehydrogenase
-
Mus musculus

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Mus musculus