Cloned (Comment) | Organism |
---|---|
expression in Escherichia coli | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
A13G/A14S/Q15K/D36S/W37R | no activity | Homo sapiens |
A14S/Q15K/D36S/W37R | no activity | Homo sapiens |
Q15K | approx. 200% of wild-type activity | Homo sapiens |
Q15K/D36A/W37R | no activity with NAD+ as cofactor, low activity with NADP+ as cofactor | Homo sapiens |
Q15K/D36S/W37R | no activity with NAD+ as cofactor, low activity with NADP+ as cofactor | Homo sapiens |
Q15K/W37K | approx. 350% of wild-type activity | Homo sapiens |
Q15K/W37R | approx. 350% of wild-type activity, strong activity with NADP+ as cofactor | Homo sapiens |
Q15R | approx. 100% of wild-type activity | Homo sapiens |
Q15R/W37K | approx. 200% of wild-type activity | Homo sapiens |
Q15R/W37R | approx. 200% of wild-type activity, strong activity with NADP+ as cofactor | Homo sapiens |
W37K | approx. 100% of wild-type activity | Homo sapiens |
W37R | approx. 100% of wild-type activity | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0063 | - |
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate | 37°C, pH 7.5 | Homo sapiens | |
0.013 | - |
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate | 37°C, pH 7.5, Q15K/W37K double mutant | Homo sapiens | |
0.026 | - |
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate | 37°C, pH 7.5, Q15K mutant | Homo sapiens | |
0.032 | - |
NAD+ | 37°C, pH 7.5 | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+ | Homo sapiens | - |
(5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
recombinant 15-PGDH | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
placenta | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+ | - |
Homo sapiens | (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
15-PGDH | - |
Homo sapiens |