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Literature summary for 1.1.1.141 extracted from
- Induction of NAD+-linked 15-hydroxyprostaglandin dehydrogenase expression by androgens in human prostate cancer cells (2000), Biochem. Biophys. Res. Commun., 276, 77-81.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| 17beta-estradiol | slight activation | Homo sapiens |  |
| dihydrotestosterone | - |
Homo sapiens | |
| additional information | the enzyme is induced by the androgens dihydrotestosterone or testosterone and, to a lesser extent, by 17beta-estradiol and progesterone in androgen-sensitive LNCaP cells, not in hormone-independent PC3 cells, the induction of 15-PGDH is not blocked by steroid receptor antagonist RU 486 nor by antiandrogen, flutamide, but is inhibited by tyrosine kinase inhibitor, genistein, and by ERK kinase inhibitor, PD 98059, but not by protein kinase C inhibitor GF109203X, thus androgens induce 15-PGDH gene expression through an unconventional nongenomic pathway, no induction by dexamethasone, hydrocortisone, and RU 486 | Homo sapiens | |
| progesterone | - |
Homo sapiens | |
| testosterone | - |
Homo sapiens | |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| genistein | - |
Homo sapiens | |
| PD 98059 | an ERK kinase inhibitor | Homo sapiens | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+ | Homo sapiens | key step in prostaglandin inactivation | (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+ | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| LNCaP cell | - |
Homo sapiens | - |
| prostate cancer cell | - |
Homo sapiens | - |
| prostate gland | androgen-sensitive cancer cells LNCaP and hormone-independent PC3 cells, enzyme expression is induced by steroids | Homo sapiens | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
in vivo activity in absence and presence of different androgens, overview | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+ | i.e. 15-hydroxyprostaglandin or (15S)-PGE2 | Homo sapiens | (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+ | - |
? | |
| (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+ | key step in prostaglandin inactivation | Homo sapiens | (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+ | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 15-PGDH | - |
Homo sapiens |
| NAD+-linked 15-hydroxyprostaglandin dehydrogenase | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | - |
assay at | Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NAD+ | - |
Homo sapiens | |
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