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Literature summary for 1.1.1.141 extracted from
- Inhibition by indomethacin and aspirin of 15-hydroxyprostaglandin dehydrogenase in vitro (1974), Prostaglandins, 8, 95-105.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Acetylsalicylate | - |
Bos taurus |  |
| indomethacin | - |
Bos taurus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0034 | - |
prostaglandin E1 | - |
Bos taurus | |
| 0.11 | - |
NAD+ | - |
Bos taurus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 40000 | - |
gel filtration | Bos taurus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Bos taurus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| lung | - |
Bos taurus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.0014 | - |
enzyme from lung | Bos taurus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+ | - |
Bos taurus | (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+ | - |
? | |
| prostaglandin E1 + NAD+ | - |
Bos taurus | 15-oxoprostaglandin E1 + NADH + H+ | - |
r | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.14 | - |
indomethacin | - |
Bos taurus | |
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Release 2023.1 (January 2023)
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