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Literature summary for 1.1.1.138 extracted from

  • Horer, S.; Stoop, J.; Mooibroek, H.; Baumann, U.; Sassoon, J.
    The crystallographic structure of the mannitol 2-dehydrogenase NADP+ binary complex from Agaricus bisporus (2001), J. Biol. Chem., 276, 27555-27561.
    View publication on PubMed

Application

Application Comment Organism
synthesis commercial mannitol production as alternatives to less efficient chemical reduction of fructose Agaricus bisporus

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Agaricus bisporus

Crystallization (Commentary)

Crystallization (Comment) Organism
binary complex with NADP+ Agaricus bisporus
binary complex with NADP+ at 1.5 A resolution, catalytic triad is assigned to Ser149, Tyr169 and Lys173 Agaricus bisporus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
D-fructose + NADPH Agaricus bisporus
-
D-mannitol + NADP+
-
r
D-mannitol + NADP+ Agaricus bisporus mannitol serves as storage carbon, plays a critical role in growth, fruit body development, osmoregulation and salt tolerance D-fructose + NADPH + H+
-
r

Organism

Organism UniProt Comment Textmining
Agaricus bisporus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
fruit body
-
Agaricus bisporus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-fructose + NADPH
-
Agaricus bisporus D-mannitol + NADP+
-
r
D-mannitol + NADP+ mannitol serves as storage carbon, plays a critical role in growth, fruit body development, osmoregulation and salt tolerance Agaricus bisporus D-fructose + NADPH + H+
-
r

Subunits

Subunits Comment Organism
tetramer data from X-ray structure Agaricus bisporus
tetramer crystallization data, residues Ser149, Tyr169, Lys173 form a catalytic triad Agaricus bisporus

Synonyms

Synonyms Comment Organism
MtDH
-
Agaricus bisporus

Cofactor

Cofactor Comment Organism Structure
NADP+ specific for NADP+ Agaricus bisporus
NADPH
-
Agaricus bisporus