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Literature summary for 1.1.1.138 extracted from

  • Boutelje, J.; Hult, K.; Gatenbeck, S.
    Mannitol dehydrogenase from industrial waste mycelium of Penicillium chrysogenum. Purification, properties and possible use in cofactor regenerating systems in vitro (1983), Eur. J. Appl. Microbiol. Biotechnol., 17, 7-12.
No PubMed abstract available

Inhibitors

Inhibitors Comment Organism Structure
Cd2+ 65% inhibition at 0.002 mM Penicillium chrysogenum
Cu2+ complete inhibition at 1 mM Penicillium chrysogenum
Fe2+ 86% inhibition at 1 mM Penicillium chrysogenum
Hg2+ complete inhibition at 1 mM Penicillium chrysogenum
Mn2+ 11% inhibition at 1 mM Penicillium chrysogenum
NADP+ Ki: 0.021 mM Penicillium chrysogenum
Sn2+ 29% inhibition at 1 mM Penicillium chrysogenum
Zn2+ 30% inhibition at 0.02 mM Penicillium chrysogenum

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.014
-
NADP+
-
Penicillium chrysogenum
0.76
-
D-mannitol
-
Penicillium chrysogenum

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ 35% activation at 10 mM Penicillium chrysogenum

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
40000
-
4 * 40000, SDS-PAGE Penicillium chrysogenum
160000
-
gel filtration Penicillium chrysogenum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
D-mannitol + NADP+ Penicillium chrysogenum
-
D-fructose + NADPH + H+
-
?

Organism

Organism UniProt Comment Textmining
Penicillium chrysogenum
-
-
-

Purification (Commentary)

Purification (Comment) Organism
to homogeneity, chromatography techniques Penicillium chrysogenum

Source Tissue

Source Tissue Comment Organism Textmining
mycelium
-
Penicillium chrysogenum
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
18.1
-
-
Penicillium chrysogenum

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-mannitol + NADP+
-
Penicillium chrysogenum D-fructose + NADPH + H+
-
?
L-arabinitol + NADP+ 5% of the activity compared to D-mannitol Penicillium chrysogenum L-xylulose + NADPH + H+
-
?
L-sorbitol + NADP+ 4% of the activity compared to D-mannitol Penicillium chrysogenum L-sorbose + NADPH
-
r

Subunits

Subunits Comment Organism
tetramer 4 * 40000, SDS-PAGE Penicillium chrysogenum

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
30
-
50 mM MOPS-KOH buffer, pH 6.0, stable for 5 days Penicillium chrysogenum

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.3
-
50 mM MOPS-KOH buffer Penicillium chrysogenum

pH Stability

pH Stability pH Stability Maximum Comment Organism
6
-
50 mM MOPS-KOH buffer, after an initial loss of 25% of activity stable for 5 days at 30°C Penicillium chrysogenum

Cofactor

Cofactor Comment Organism Structure
NADP+ cannot be replaced by NAD+ Penicillium chrysogenum