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Literature summary for 1.1.1.102 extracted from

  • Kim, S.; Noh, Y.; Koo, J.; Da Silva, N.; Yun, H.
    Effects of expression of lcb1/lcb2 and lac1/lag1 genes on the biosynthesis of ceramides (2011), Biotechnol. Bioprocess Eng., 16, 1-6.
No PubMed abstract available

Protein Variants

Protein Variants Comment Organism
additional information cobstruction of a tsc10 knockout mutant strain, analysis of lipid and ceramide profiles compared to wild-type strain, quantitative real time RT-PCR expression analysis, phenotype, overview Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3-oxosphinganine + NADPH + H+ Saccharomyces cerevisiae
-
D-erythro-dihydrosphingosine + L-threo-dihydrosphingosine + NADP+
-
?
3-oxosphinganine + NADPH + H+ Saccharomyces cerevisiae KCCM 50515
-
D-erythro-dihydrosphingosine + L-threo-dihydrosphingosine + NADP+
-
?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
gene tsc10
-
Saccharomyces cerevisiae KCCM 50515
-
gene tsc10
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3-oxosphinganine + NADPH + H+
-
Saccharomyces cerevisiae D-erythro-dihydrosphingosine + L-threo-dihydrosphingosine + NADP+
-
?
3-oxosphinganine + NADPH + H+
-
Saccharomyces cerevisiae KCCM 50515 D-erythro-dihydrosphingosine + L-threo-dihydrosphingosine + NADP+
-
?

Synonyms

Synonyms Comment Organism
3-ketosphinganine reductase
-
Saccharomyces cerevisiae

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Saccharomyces cerevisiae