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Literature summary for 1.1.1.102 extracted from

  • Kihara, A.; Igarashi, Y.
    FVT-1 is a mammalian 3-ketodihydrosphingosine reductase with an active site that faces the cytosolic side of the endoplasmic reticulum membrane (2004), J. Biol. Chem., 279, 49243-49250.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression in yeast cells Homo sapiens
expression in yeast cells Mus musculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.003
-
3-ketodihydrosphingosine pH 7.5, 37°C Homo sapiens
0.028
-
NADPH pH 7.5, 37°C Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum
-
Homo sapiens 5783
-
endoplasmic reticulum
-
Mus musculus 5783
-
membrane of endoplasmic reticulum Mus musculus 16020
-
membrane of endoplasmic reticulum, the large hydrophilic domain, which contains putative active site residues, faces the cytosol Homo sapiens 16020
-

Organism

Organism UniProt Comment Textmining
Homo sapiens Q06136
-
-
Mus musculus Q6GV12
-
-

Source Tissue

Source Tissue Comment Organism Textmining
colon low expression Homo sapiens
-
heart high expression Homo sapiens
-
heart low level of expression Mus musculus
-
kidney high expression Mus musculus
-
leukocyte pheripheral blood, low expression Homo sapiens
-
lung high expression Mus musculus
-
placenta highest expression Mus musculus
-
skeletal muscle high expression Homo sapiens
-
skeletal muscle low level of expression Mus musculus
-
small intestine high expression Mus musculus
-
spleen low level of expression Mus musculus
-
stomach high expression Mus musculus
-
thymus low expression Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3-ketodihydrosphingosine + NADPH
-
Homo sapiens dihydrosphingosine + NADP+
-
?
3-ketodihydrosphingosine + NADPH
-
Mus musculus dihydrosphingosine + NADP+
-
?

Synonyms

Synonyms Comment Organism
3-ketodihydrosphingosine reductase
-
Homo sapiens
3-ketodihydrosphingosine reductase
-
Mus musculus
FVT-1
-
Homo sapiens
FVT-1
-
Mus musculus
h-FTV-1
-
Homo sapiens
KDS reductase
-
Homo sapiens
KDS reductase
-
Mus musculus
m-FTV-1
-
Mus musculus

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Homo sapiens
NADPH
-
Mus musculus