Cloned (Comment) | Organism |
---|---|
expression in yeast cells | Homo sapiens |
expression in yeast cells | Mus musculus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.003 | - |
3-ketodihydrosphingosine | pH 7.5, 37°C | Homo sapiens | |
0.028 | - |
NADPH | pH 7.5, 37°C | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
endoplasmic reticulum | - |
Homo sapiens | 5783 | - |
endoplasmic reticulum | - |
Mus musculus | 5783 | - |
membrane | of endoplasmic reticulum | Mus musculus | 16020 | - |
membrane | of endoplasmic reticulum, the large hydrophilic domain, which contains putative active site residues, faces the cytosol | Homo sapiens | 16020 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q06136 | - |
- |
Mus musculus | Q6GV12 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
colon | low expression | Homo sapiens | - |
heart | high expression | Homo sapiens | - |
heart | low level of expression | Mus musculus | - |
kidney | high expression | Mus musculus | - |
leukocyte | pheripheral blood, low expression | Homo sapiens | - |
lung | high expression | Mus musculus | - |
placenta | highest expression | Mus musculus | - |
skeletal muscle | high expression | Homo sapiens | - |
skeletal muscle | low level of expression | Mus musculus | - |
small intestine | high expression | Mus musculus | - |
spleen | low level of expression | Mus musculus | - |
stomach | high expression | Mus musculus | - |
thymus | low expression | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3-ketodihydrosphingosine + NADPH | - |
Homo sapiens | dihydrosphingosine + NADP+ | - |
? | |
3-ketodihydrosphingosine + NADPH | - |
Mus musculus | dihydrosphingosine + NADP+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
3-ketodihydrosphingosine reductase | - |
Homo sapiens |
3-ketodihydrosphingosine reductase | - |
Mus musculus |
FVT-1 | - |
Homo sapiens |
FVT-1 | - |
Mus musculus |
h-FTV-1 | - |
Homo sapiens |
KDS reductase | - |
Homo sapiens |
KDS reductase | - |
Mus musculus |
m-FTV-1 | - |
Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Homo sapiens | |
NADPH | - |
Mus musculus |