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Literature summary for 1.1.1.100 extracted from

  • Silva, R.G.; de Carvalho, L.P.; Blanchard, J.S.; Santos, D.S.; Basso, L.A.
    Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein (ACP) reductase: kinetic and chemical mechanisms (2006), Biochemistry, 45, 13064-13073.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
3-hydroxybutyryl-CoA noncompetitive product inhibition pattern Mycobacterium tuberculosis
NADP+ noncompetitive product inhibition pattern Mycobacterium tuberculosis

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information detailed kinetic and thermodynamic analysis, solvent and multiple kinetic isotope effects, kinetic mechanism Mycobacterium tuberculosis
0.026
-
NADPH pH 7.6, 30°C Mycobacterium tuberculosis
0.165
-
acetoacetyl-CoA pH 7.6, 30°C Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3-oxoacyl-[acyl-carrier protein] + NADPH Mycobacterium tuberculosis
-
3-hydroxyacyl-[acyl-carrier protein] + NADP+
-
r

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis
-
gene mabA
-

Reaction

Reaction Comment Organism Reaction ID
a (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ = a 3-oxoacyl-[acyl-carrier protein] + NADPH + H+ chemical and kinetic mechanism Mycobacterium tuberculosis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3-oxoacyl-[acyl-carrier protein] + NADPH
-
Mycobacterium tuberculosis 3-hydroxyacyl-[acyl-carrier protein] + NADP+
-
r
acetoacetyl-CoA + NADPH
-
Mycobacterium tuberculosis 3-hydroxybutyryl-CoA + NADP+
-
r

Synonyms

Synonyms Comment Organism
ACP reductase
-
Mycobacterium tuberculosis
beta-ketoacyl-acyl carrier protein reductase
-
Mycobacterium tuberculosis
MabA
-
Mycobacterium tuberculosis

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
assay at Mycobacterium tuberculosis

Temperature Range [°C]

Temperature Minimum [°C] Temperature Maximum [°C] Comment Organism
15 37 temperature profile Mycobacterium tuberculosis

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
7
-
acetoacetyl-CoA pH 7.0, 25°C Mycobacterium tuberculosis
7
-
NADPH pH 7.6, 30°C Mycobacterium tuberculosis

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
assay at Mycobacterium tuberculosis

pH Range

pH Minimum pH Maximum Comment Organism
5.8 10 pH profile, pH-dependence analysis, overview Mycobacterium tuberculosis

Cofactor

Cofactor Comment Organism Structure
NADP+
-
Mycobacterium tuberculosis
NADPH
-
Mycobacterium tuberculosis

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
additional information
-
additional information product inhibition kinetics, overview Mycobacterium tuberculosis