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Literature summary for 1.1.1.1 extracted from

  • Friest, J.A.; Maezato, Y.; Broussy, S.; Blum, P.; Berkowitz, D.B.
    Use of a robust dehydrogenase from an archael hyperthermophile in asymmetric catalysis-dynamic reductive kinetic resolution entry into (S)-profens (2010), J. Am. Chem. Soc., 132, 5930-5931.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli host strain PBL339 Saccharolobus solfataricus

Organism

Organism UniProt Comment Textmining
Saccharolobus solfataricus P39462
-
-
Saccharolobus solfataricus P2 P39462
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-(3,5-dimethylphenyl)propanal + NADH + H+ 18 h, 99% yield, 90% enantiomeric excess Saccharolobus solfataricus (S)-2-(3,5-dimethylphenyl)propanol + NAD+
-
?
2-(3,5-dimethylphenyl)propanal + NADH + H+ 18 h, 99% yield, 90% enantiomeric excess Saccharolobus solfataricus P2 (S)-2-(3,5-dimethylphenyl)propanol + NAD+
-
?
2-(3-benzoylphenyl)propanal + NADH + H+ 18 h, 85% yield, 95% enantiomeric excess Saccharolobus solfataricus (S)-2-(3-benzoylphenyl)propanol + NAD+
-
?
2-(3-benzoylphenyl)propanal + NADH + H+ 18 h, 85% yield, 95% enantiomeric excess Saccharolobus solfataricus P2 (S)-2-(3-benzoylphenyl)propanol + NAD+
-
?
2-(3-fluorobiphenyl-4-yl)propanal + NADH + H+ 18 h, 77% yield, 97% enantiomeric excess Saccharolobus solfataricus (S)-2-(3-(fluoro)biphenyl-4-yl)propanol + NAD+
-
?
2-(3-fluorobiphenyl-4-yl)propanal + NADH + H+ 18 h, 77% yield, 97% enantiomeric excess Saccharolobus solfataricus P2 (S)-2-(3-(fluoro)biphenyl-4-yl)propanol + NAD+
-
?
2-(3-phenoxyphenyl)propanal + NADH + H+ 18 h, 85% yield, 95% enantiomeric excess Saccharolobus solfataricus (S)-2-((3-phenoxy)phenyl)propanol + NAD+
-
?
2-(3-phenoxyphenyl)propanal + NADH + H+ 18 h, 85% yield, 95% enantiomeric excess Saccharolobus solfataricus P2 (S)-2-((3-phenoxy)phenyl)propanol + NAD+
-
?
2-(4-isobutylphenyl)propanal + NADH + H+ 18 h, 92% yield, 99% enantiomeric excess Saccharolobus solfataricus (S)-2-(4-isobutylphenyl)propanol + NAD+
-
?
2-(4-isobutylphenyl)propanal + NADH + H+ 18 h, 92% yield, 99% enantiomeric excess Saccharolobus solfataricus P2 (S)-2-(4-isobutylphenyl)propanol + NAD+
-
?
2-(4-trifluoromethylphenyl)propanal + NADH + H+ 18 h, 55% yield, 98% enantiomeric excess Saccharolobus solfataricus (S)-2-(4-trifluoromethyl)phenylpropanol + NAD+
-
?
2-(6-methoxynaphthalen-2-yl)propanal + NADH + H+ 18 h, 96% yield, 98% enantiomeric excess Saccharolobus solfataricus (S)-2-(6-methoxynaphthalen-2-yl)propan-1-ol + NAD+
-
?
2-(naphthalen-1-yl)propanal + NADH + H+ 18 h, 90% yield, 80% enantiomeric excess Saccharolobus solfataricus (S)-2-(naphthalen-1-yl)propanol + NAD+
-
?
2-(naphthalen-2-yl)propanal + NADH + H+ 18 h, 57% yield, 94% enantiomeric excess Saccharolobus solfataricus (S)-2-(naphthalen-2-yl)propanol + NAD+
-
?
2-phenylpropanal + NADH + H+ 18 h, 74% yield, 98% enantiomeric excess Saccharolobus solfataricus (S)-2-phenylpropanol + NAD+
-
?
2-[3-(2-phenyl-1,3-dioxolan-2-yl)phenyl]propanal + NADH + H+ 18 h, 95% yield, 61% enantiomeric excess Saccharolobus solfataricus (S)-2-(3-(2-phenyl-1,3-dioxolan-2-yl)phenyl)propanol + NAD+
-
?

Synonyms

Synonyms Comment Organism
ADH-10
-
Saccharolobus solfataricus
alcohol dehydrogenase 10
-
Saccharolobus solfataricus
SsADH-10
-
Saccharolobus solfataricus
SSO2536 locus name Saccharolobus solfataricus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
80
-
assay at Saccharolobus solfataricus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
9
-
assay at Saccharolobus solfataricus