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Literature summary for 1.1.1.1 extracted from

  • Quintanilla, M.E.; Tampier, L.; Sapag, A.; Gerdtzen, Z.; Israel, Y.
    Sex differences, alcohol dehydrogenase, acetaldehyde burst, and aversion to ethanol in the rat: a systems perspective (2007), Am. J. Physiol. Endocrinol. Metab., 293, E531-E537.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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Source Tissue

Source Tissue Comment Organism Textmining
liver females show 70% higher hepatic alcohol dehydrogenase activity and display 60% lower voluntary ethanol intake than males. Following ethanol administration (1 g/kg ip), females generate a transient blood acetaldehyde increase with levels that are 2.5fold greater than in males. Castration of males leads to an increase alcohol dehydrogenase activity the appearance of an acetaldehyde burst a reduction of voluntary ethanol intake comparable with that of females Rattus norvegicus
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