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Literature summary for 1.1.1.1 extracted from

  • Martras, S.; Alvarez, R.; Gallego, O.; Dominguez, M.; de Lera, A.R.; Farres, J.; Pares, X.
    Kinetics of human alcohol dehydrogenase with ring-oxidized retinoids: effect of Tween 80 (2004), Arch. Biochem. Biophys., 430, 210-217.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
Tween 80 competitive, stabilizes the retinoid compounds, elevates the Km values of the substrates, most effective at 0.1% w/v Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.004
-
4-hydroxy-retinol pH 7.5, 25°C, isozyme ADH1B1 Homo sapiens
0.011
-
all-trans-retinal pH 7.5, 25°C, isozyme ADH1B1 Homo sapiens
0.011
-
4-hydroxy-retinol pH 7.5, 25°C, isozyme ADH1B2 Homo sapiens
0.012
-
all-trans-retinal pH 7.5, 25°C, isozyme ADH1B2 Homo sapiens
0.015
-
4-hydroxy-retinol pH 7.5, 25°C, isozyme ADH4 Homo sapiens
0.017
-
4-oxo-retinal pH 7.5, 25°C, isozyme ADH4 Homo sapiens
0.023
-
all-trans-retinol pH 7.5, 25°C, isozyme ADH4 Homo sapiens
0.024
-
3,4-dihydro-retinol pH 7.5, 25°C, isozyme ADH1B2 Homo sapiens
0.025
-
4-oxo-retinal pH 7.5, 25°C, isozyme ADH1B1 Homo sapiens
0.025
-
3,4-dihydro-retinal pH 7.5, 25°C, isozyme ADH1B2 Homo sapiens
0.026
-
3,4-dihydro-retinal pH 7.5, 25°C, isozyme ADH4 Homo sapiens
0.027
-
4-oxo-retinal pH 7.5, 25°C, isozyme ADH1B2 Homo sapiens
0.028
-
3,4-dihydro-retinol pH 7.5, 25°C, isozyme ADH4 Homo sapiens
0.03
-
all-trans-retinol pH 7.5, 25°C, isozyme ADH1B1 Homo sapiens
0.033
-
all-trans-retinol pH 7.5, 25°C, isozyme ADH1B2 Homo sapiens
0.034
-
all-trans-retinal pH 7.5, 25°C, isozyme ADH4 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3,4-dihydro-retinol + NAD+
-
Homo sapiens 3,4-dihydro-retinal
-
r
4-hydroxy-retinol + NAD+
-
Homo sapiens 4-oxo-retinal + NADH
-
r
all-trans-retinol + NAD+
-
Homo sapiens all-trans-retinal + NADH
-
r

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
assay at Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.018
-
all-trans-retinal pH 7.5, 25°C, isozyme ADH1B1 Homo sapiens
0.028
-
all-trans-retinol pH 7.5, 25°C, isozyme ADH1B1 Homo sapiens
0.088
-
3,4-dihydro-retinol pH 7.5, 25°C, isozyme ADH1B2 Homo sapiens
0.092
-
4-hydroxy-retinol pH 7.5, 25°C, isozyme ADH1B1 Homo sapiens
0.167
-
4-oxo-retinal pH 7.5, 25°C, isozyme ADH1B1 Homo sapiens
0.22
-
3,4-dihydro-retinal pH 7.5, 25°C, isozyme ADH1B2 Homo sapiens
0.25
-
all-trans-retinol pH 7.5, 25°C, isozyme ADH1B2 Homo sapiens
0.55
-
all-trans-retinal pH 7.5, 25°C, isozyme ADH1B2 Homo sapiens
0.9
-
all-trans-retinol pH 7.5, 25°C, isozyme ADH4 Homo sapiens
1.22
-
3,4-dihydro-retinal pH 7.5, 25°C, isozyme ADH4 Homo sapiens
1.83
-
all-trans-retinal pH 7.5, 25°C, isozyme ADH4 Homo sapiens
2.5
-
3,4-dihydro-retinol pH 7.5, 25°C, isozyme ADH4 Homo sapiens
2.83
-
4-hydroxy-retinol pH 7.5, 25°C, isozyme ADH1B2 Homo sapiens
7.83
-
4-oxo-retinal pH 7.5, 25°C, isozyme ADH1B2 Homo sapiens
20
-
4-oxo-retinal pH 7.5, 25°C, isozyme ADH4 Homo sapiens
34.2
-
4-hydroxy-retinol pH 7.5, 25°C, isozyme ADH4 Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
assay at Homo sapiens