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Literature summary for 1.1.1.1 extracted from

  • Keung, W.M.
    Isolation and characterization of three alcohol dehydrogenase isozymes from Syrian golden hamster (1996), Alcohol. Clin. Exp. Res., 20, 213-220.
    View publication on PubMed
Search for more literature for 1.1.1.1

Inhibitors

Inhibitors Comment Organism Structure
1,10-phenanthroline
-
 Mesocricetus auratus
4-Methylpyrazole isoenzyme AA-ADH, BB-ADH and TT-ADH Mesocricetus auratus
Biochanin A inhibition of isoenzyme BB-ADH, no inhibition of isoenzyme AA-ADH and TT-ADH Mesocricetus auratus
daidzein inhibition of isoenzyme BB-ADH, no inhibition of isoenzyme AA-ADH and TT-ADH Mesocricetus auratus
genistein inhibition of isoenzyme BB-ADH, no inhibition of isoenzyme AA-ADH and TT-ADH Mesocricetus auratus
testosterone inhibition of isoenzyme BB-ADH, no inhibition of isoenzyme AA-ADH and TT-ADH Mesocricetus auratus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.02
-
 all-trans-retinol isoenzyme TT-ADH Mesocricetus auratus
0.02
-
 n-Hexanol isoenzyme TT-ADH Mesocricetus auratus
0.02
-
 12-hydroxydodecanoate isoenzyme BB-ADH Mesocricetus auratus
0.03
-
 n-butanol isoenzyme BB-ADH Mesocricetus auratus
0.03
-
 all-trans-retinol isoenzyme BB-ADH Mesocricetus auratus
0.04
-
 Cyclohexanol isoenzyme BB-ADH Mesocricetus auratus
0.04
-
 n-Hexanol isoenzyme BB-ADH Mesocricetus auratus
0.05
-
 12-hydroxydodecanoate isoenzyme BB-ADH and isoenzyme ADH-TT Mesocricetus auratus
0.05
-
 all-trans-retinol isoenzyme AA-ADH Mesocricetus auratus
0.06
-
 12-hydroxydodecanoate isoenzyme AA-ADH Mesocricetus auratus
0.07
-
 n-butanol isoenzyme AA-ADH Mesocricetus auratus
0.26
-
 n-Hexanol isoenzyme TT-ADH Mesocricetus auratus
0.5
-
 ethanol isoenzyme AA-ADH Mesocricetus auratus
0.76
-
 ethanol isoenzyme BB-ADH Mesocricetus auratus
0.76
-
 Cyclohexanol isoenzyme AA-ADH Mesocricetus auratus
2.3
-
 12-hydroxydodecanoate isoenzyme TT-ADH Mesocricetus auratus
2.6
-
 n-butanol isoenzyme TT-ADH Mesocricetus auratus
28
-
 ethanol isoenzyme TT-ADH Mesocricetus auratus
320
-
 Cyclohexanol isoenzyme TT-ADH Mesocricetus auratus

Metals/Ions

Metals/Ions Comment Organism Structure
Zinc isoenzyme AA-ADH contains 4.3 zinc atoms per dimeric molecule, isoenzyme BB-ADH contains 3.7 zinc atoms per dimeric molecule, isoenzyme AA-ADH contains 4.1 zinc atoms per dimeric molecule Mesocricetus auratus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
40000
-
 2 * 40000, SDS-PAGE Mesocricetus auratus
80000
-
 gel filtration Mesocricetus auratus

Organism

Organism UniProt Comment Textmining
Mesocricetus auratus
-
 3 major isoenzymes: TT-ADH, AA-ADH and BB-ADH
-

Source Tissue

Source Tissue Comment Organism Textmining
liver isoenzyme AA-ADH and BB-ADH most abundant in Mesocricetus auratus
-
testis isoenzyme TT-ADH is only found in testis Mesocricetus auratus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.1
-
 isoenzyme AA-ADH Mesocricetus auratus
2.5
-
 isoenzyme BB-ADH Mesocricetus auratus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
12-hydroxydodecanoate + NAD+
-
 Mesocricetus auratus 12-oxododecanoic acid + NADH
-
 ?
3beta-hydroxy-5beta-androstan-17-one + NAD+ catalyzed by isoenzyme BB-ADH, no activity with isoenzyme AA-ADH and TT-ADH Mesocricetus auratus 5beta-androstan-3,17-dione + NADH
-
 ?
all-trans-retinol + NAD+
-
 Mesocricetus auratus all-trans-retinal + NADH
-
 ?
butan-2-ol + NAD+
-
 Mesocricetus auratus butan-2-one + NADH
-
 ?
butanol + NAD+
-
 Mesocricetus auratus butyraldehyde + NADH
-
 ?
cyclohexanol + NAD+
-
 Mesocricetus auratus cyclohexanone + NADH
-
 ?
ethanol + NAD+
-
 Mesocricetus auratus acetaldehyde + NADH
-
 ?
hexanol + NAD+
-
 Mesocricetus auratus n-hexanal + NADH
-
 ?
methylcrotonyl alcohol + NAD+
-
 Mesocricetus auratus methylcrotonaldehyde + NADH
-
 ?

Subunits

Subunits Comment Organism
dimer 2 * 40000, SDS-PAGE Mesocricetus auratus

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.35
-
 all-trans retinol isoenzyme AA-ADH Mesocricetus auratus
1.03
-
 12-hydroxydodecanoate isoenzyme TT-ADH Mesocricetus auratus
1.3
-
 all-trans retinol isoenzyme TT-ADH Mesocricetus auratus
1.75
-
 Cyclohexanol isoenzyme BB-ADH Mesocricetus auratus
1.9
-
 all-trans retinol isoenzyme BB-ADH Mesocricetus auratus
2.2
-
 12-hydroxydodecanoate isoenzyme BB-ADH Mesocricetus auratus
2.35
-
 n-Hexanol isoenzyme BB-ADH Mesocricetus auratus
2.4
-
 Cyclohexanol isoenzyme AA-ADH Mesocricetus auratus
2.58
-
 n-butanol isoenzymee BB-ADH Mesocricetus auratus
2.63
-
 methylcrotonyl alcohol isoenzyme BB-ADH Mesocricetus auratus
2.77
-
 12-hydroxydodecanoate isoenzyme AA-ADH Mesocricetus auratus
2.8
-
 n-Hexanol isoenzyme AA-ADH Mesocricetus auratus
2.83
-
 ethanol isoenzyme AA-ADH Mesocricetus auratus
3
-
 methylcrotonyl alcohol isoenzyme AA-ADH Mesocricetus auratus
3.33
-
 n-butanol isoenzyme AA-ADH Mesocricetus auratus
3.38
-
 ethanol isoenzyme BB-ADH Mesocricetus auratus
4.08
-
 n-Hexanol isoenzyme TT-ADH Mesocricetus auratus
7.18
-
 n-butanol isoenzyme TT-ADH Mesocricetus auratus
8.5
-
 Cyclohexanol isoenzyme TT-ADH Mesocricetus auratus
8.58
-
 methylcrotonyl alcohol isoenzyme TT-ADH Mesocricetus auratus
9.58
-
 ethanol isoenzyme TT-ADH Mesocricetus auratus

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Mesocricetus auratus
NADH
-
 Mesocricetus auratus