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Literature summary for 1.1.1.1 extracted from

  • Mezey, E.; Potter, J.J.
    Separation and partial characterization of multiple forms of rat liver alcohol dehydrogenase (1983), Arch. Biochem. Biophys., 225, 787-794.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
4-methoxypyrazole competitive inhibitor of all four isoenzymes Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.021
-
5alpha-androstan-17beta-ol-3-one isoenzyme 2 Rattus norvegicus
0.025
-
5alpha-androstan-17beta-ol-3-one isoenzyme 2 Rattus norvegicus
0.027
-
5alpha-androstan-17beta-ol-3-one isoenzyme 4 Rattus norvegicus
0.032
-
3beta-7alpha-dihydroxy-5beta-cholanoate isoenzyme 3 Rattus norvegicus
0.04
-
5alpha-androstan-17beta-ol-3-one isoenzyme 1 Rattus norvegicus
0.044
-
NAD+ isoenzyme 4 Rattus norvegicus
0.051
-
NADH isoenzyme 4 Rattus norvegicus
0.057
-
NAD+ isoenzyme 1 Rattus norvegicus
0.064
-
3beta-7alpha-dihydroxy-5beta-cholanoate isoenzyme 2 Rattus norvegicus
0.066
-
3beta-7alpha-dihydroxy-5beta-cholanoate isoenzyme 1 Rattus norvegicus
0.071
-
NADH isoenzyme 2 Rattus norvegicus
0.071
-
3beta-7alpha-dihydroxy-5beta-cholanoate isoenzyme 4 Rattus norvegicus
0.076
-
NADH isoenzyme 1 Rattus norvegicus
0.091
-
NADH isoenzyme 3 Rattus norvegicus
0.099
-
NAD+ isoenzyme 2 Rattus norvegicus
0.115
-
NAD+ isoenzyme 2 Rattus norvegicus
0.123
-
5beta-androstan-3beta-ol-17 one isoenzyme 4 Rattus norvegicus
0.125
-
5beta-androstan-3beta-ol-17 one isoenzyme 2 Rattus norvegicus
0.128
-
3beta,12alpha-dihydroxy-5beta-cholanoate isoenzyme 2 Rattus norvegicus
0.14
-
5beta-androstan-3beta-ol-17 one isoenzyme 3 Rattus norvegicus
0.149
-
3beta,7alpha,12alpha-trihydroxy-5beta-cholanoate isoenzyme I Rattus norvegicus
0.16
-
3beta,7alpha,12alpha-trihydroxy-5beta-cholanoate isoenzyme 2 Rattus norvegicus
0.16
-
3beta,12alpha-dihydroxy-5beta-cholanoate isoenzyme 3 Rattus norvegicus
0.164
-
5beta-androstan-3beta-ol-17 one isoenzyme 1 Rattus norvegicus
0.182
-
3beta,7alpha,12alpha-trihydroxy-5beta-cholanoate isoenzyme 3 Rattus norvegicus
0.217
-
acetaldehyde isoenzyme 3 Rattus norvegicus
0.23
-
acetaldehyde isoenzyme 2 Rattus norvegicus
0.248
-
3beta,12alpha-dihydroxy-5beta-cholanoate isoenzyme 4 Rattus norvegicus
0.276
-
acetaldehyde isoenzyme 4 Rattus norvegicus
0.31
-
acetaldehyde isoenzyme 1 Rattus norvegicus
0.31
-
3beta,12alpha-dihydroxy-5beta-cholanoate isoenzyme I Rattus norvegicus
0.35
-
3beta,7alpha-12alpha-trihydroxy-5beta-cholanoate isoenzyme 4 Rattus norvegicus
0.76
-
ethanol isoenzyme 2 Rattus norvegicus
1.37
-
ethanol isoenzyme 1 Rattus norvegicus
1.41
-
ethanol isoenzyme 4 Rattus norvegicus
1.87
-
ethanol isoenzyme 3 Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
isoenzyme 1, 2, 3 and 4
-

Purification (Commentary)

Purification (Comment) Organism
isoenzyme 1, 2, 3, and 4 Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3beta,12alpha-dihydroxy-5beta-cholanoic acid + NAD+
-
Rattus norvegicus ? + NADH
-
?
3beta,7alpha,12alpha-trihydroxy-5beta-cholanoic acid + NAD+
-
Rattus norvegicus ? + NADH
-
?
3beta,7alpha-dihydroxy-5beta-cholanoic acid + NAD+
-
Rattus norvegicus ? + NADH
-
?
3beta-7alpha-dihydroxy-5beta-cholanoate + NAD+
-
Rattus norvegicus 17-hydroxy-3-oxo-5beta-cholanoate + NADH + H+
-
r
3beta-hydroxy-5beta-androstan-17-one + NAD+
-
Rattus norvegicus 5beta-androstan-3,17-dione + NADH
-
?
5alpha-androstan-17beta-ol-3-one + NADH + H+
-
Rattus norvegicus 3beta,17beta-dihydroxy-5alpha-androstan + NAD+
-
?
acetaldehyde + NADH + H+
-
Rattus norvegicus ethanol + NAD+
-
r
ethanol + NAD+
-
Rattus norvegicus acetaldehyde + NADH
-
r

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
9.5
-
oxidation of ethanol Rattus norvegicus
9.5
-
isoenzyme 1 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Rattus norvegicus
NADH
-
Rattus norvegicus