Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4-methoxypyrazole | competitive inhibitor of all four isoenzymes | Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.021 | - |
5alpha-androstan-17beta-ol-3-one | isoenzyme 2 | Rattus norvegicus | |
0.025 | - |
5alpha-androstan-17beta-ol-3-one | isoenzyme 2 | Rattus norvegicus | |
0.027 | - |
5alpha-androstan-17beta-ol-3-one | isoenzyme 4 | Rattus norvegicus | |
0.032 | - |
3beta-7alpha-dihydroxy-5beta-cholanoate | isoenzyme 3 | Rattus norvegicus | |
0.04 | - |
5alpha-androstan-17beta-ol-3-one | isoenzyme 1 | Rattus norvegicus | |
0.044 | - |
NAD+ | isoenzyme 4 | Rattus norvegicus | |
0.051 | - |
NADH | isoenzyme 4 | Rattus norvegicus | |
0.057 | - |
NAD+ | isoenzyme 1 | Rattus norvegicus | |
0.064 | - |
3beta-7alpha-dihydroxy-5beta-cholanoate | isoenzyme 2 | Rattus norvegicus | |
0.066 | - |
3beta-7alpha-dihydroxy-5beta-cholanoate | isoenzyme 1 | Rattus norvegicus | |
0.071 | - |
NADH | isoenzyme 2 | Rattus norvegicus | |
0.071 | - |
3beta-7alpha-dihydroxy-5beta-cholanoate | isoenzyme 4 | Rattus norvegicus | |
0.076 | - |
NADH | isoenzyme 1 | Rattus norvegicus | |
0.091 | - |
NADH | isoenzyme 3 | Rattus norvegicus | |
0.099 | - |
NAD+ | isoenzyme 2 | Rattus norvegicus | |
0.115 | - |
NAD+ | isoenzyme 2 | Rattus norvegicus | |
0.123 | - |
5beta-androstan-3beta-ol-17 one | isoenzyme 4 | Rattus norvegicus | |
0.125 | - |
5beta-androstan-3beta-ol-17 one | isoenzyme 2 | Rattus norvegicus | |
0.128 | - |
3beta,12alpha-dihydroxy-5beta-cholanoate | isoenzyme 2 | Rattus norvegicus | |
0.14 | - |
5beta-androstan-3beta-ol-17 one | isoenzyme 3 | Rattus norvegicus | |
0.149 | - |
3beta,7alpha,12alpha-trihydroxy-5beta-cholanoate | isoenzyme I | Rattus norvegicus | |
0.16 | - |
3beta,7alpha,12alpha-trihydroxy-5beta-cholanoate | isoenzyme 2 | Rattus norvegicus | |
0.16 | - |
3beta,12alpha-dihydroxy-5beta-cholanoate | isoenzyme 3 | Rattus norvegicus | |
0.164 | - |
5beta-androstan-3beta-ol-17 one | isoenzyme 1 | Rattus norvegicus | |
0.182 | - |
3beta,7alpha,12alpha-trihydroxy-5beta-cholanoate | isoenzyme 3 | Rattus norvegicus | |
0.217 | - |
acetaldehyde | isoenzyme 3 | Rattus norvegicus | |
0.23 | - |
acetaldehyde | isoenzyme 2 | Rattus norvegicus | |
0.248 | - |
3beta,12alpha-dihydroxy-5beta-cholanoate | isoenzyme 4 | Rattus norvegicus | |
0.276 | - |
acetaldehyde | isoenzyme 4 | Rattus norvegicus | |
0.31 | - |
acetaldehyde | isoenzyme 1 | Rattus norvegicus | |
0.31 | - |
3beta,12alpha-dihydroxy-5beta-cholanoate | isoenzyme I | Rattus norvegicus | |
0.35 | - |
3beta,7alpha-12alpha-trihydroxy-5beta-cholanoate | isoenzyme 4 | Rattus norvegicus | |
0.76 | - |
ethanol | isoenzyme 2 | Rattus norvegicus | |
1.37 | - |
ethanol | isoenzyme 1 | Rattus norvegicus | |
1.41 | - |
ethanol | isoenzyme 4 | Rattus norvegicus | |
1.87 | - |
ethanol | isoenzyme 3 | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
isoenzyme 1, 2, 3 and 4 | - |
Purification (Comment) | Organism |
---|---|
isoenzyme 1, 2, 3, and 4 | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3beta,12alpha-dihydroxy-5beta-cholanoic acid + NAD+ | - |
Rattus norvegicus | ? + NADH | - |
? | |
3beta,7alpha,12alpha-trihydroxy-5beta-cholanoic acid + NAD+ | - |
Rattus norvegicus | ? + NADH | - |
? | |
3beta,7alpha-dihydroxy-5beta-cholanoic acid + NAD+ | - |
Rattus norvegicus | ? + NADH | - |
? | |
3beta-7alpha-dihydroxy-5beta-cholanoate + NAD+ | - |
Rattus norvegicus | 17-hydroxy-3-oxo-5beta-cholanoate + NADH + H+ | - |
r | |
3beta-hydroxy-5beta-androstan-17-one + NAD+ | - |
Rattus norvegicus | 5beta-androstan-3,17-dione + NADH | - |
? | |
5alpha-androstan-17beta-ol-3-one + NADH + H+ | - |
Rattus norvegicus | 3beta,17beta-dihydroxy-5alpha-androstan + NAD+ | - |
? | |
acetaldehyde + NADH + H+ | - |
Rattus norvegicus | ethanol + NAD+ | - |
r | |
ethanol + NAD+ | - |
Rattus norvegicus | acetaldehyde + NADH | - |
r |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
9.5 | - |
oxidation of ethanol | Rattus norvegicus |
9.5 | - |
isoenzyme 1 | Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Rattus norvegicus | |
NADH | - |
Rattus norvegicus |